Diagnosis and prognostic assessment of the volume ratio of peritumoral edema to tumor core in gliomas
Objective To evaluate the clinical value of a novel metric,the volume ratio of peritumoral edema(VPE)to tumor core(VTC),in the diagnosis and prognostic assessment of brain gliomas using MRI.Methods A retrospective analysis was conducted on preoperative MRI data and clinical records of 51 patients with brain gliomas admitted to the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to June 2023.The cohort included 22 cases of low-grade gliomas(LGG)and 29 cases of high-grade gliomas(HGG).Tumor core and peritumoral edema regions were delineated semi-automatically using 3D-Slicer software following MRI sequence registration,with manual adjustments to ensure accuracy.Three-dimensional models of the core and edema regions were constructed for quantitative analysis,and the VPE/VTC ratio was calculated.Results The VPE/VTC ratio was significantly higher in the HGG group than in the LGG group(P<0.05).The VPE/VTC ratio demonstrated high diagnostic performance in distinguishing HGG from LGG(AUC=0.851),with an optimal cut-off value of 0.929,achieving the highest Youden index of 0.771,sensitivity of 86.2%,and specificity of 90.9%.Kaplan-Meier survival analysis revealed that patients with higher VPE/VTC ratios had poorer prognoses(P<0.05),indicating its strong predictive ability for prognosis evaluation.Conclusion As a novel evaluation metric,the VPE/VTC ratio holds significant clinical value and provides more effective support for individualized treatment and surgical planning in patients with brain gliomas.
国家科技期刊平台
NSTL
万方数据
