Correlation between the contrast enhanced mammography signs and different molecular subtypes of mass breast cancer
Objective To investigate the correlation between the imaging of contrast-enhanced mammography(CEM)and different molecular subtypes of mass breast cancer.Methods The clinical,pathological and imaging data from 220 patients who were initially diagnosed with mass breast cancer were collected from February 2018 to December 2021.All patients underwent routine CEM before surgery,and were divided into Luminal A,Luminal B,HER2-enriched,and triple-negative subtype according to immunohistochemistry.According to the breast imaging report and data system(BI-RADS)of CEM,the imaging signs of patients with low energy images and subtraction images were extracted respectively,including 11 features such as tumor shape,margin and enhancement degree.Finally,the relationship between different molecular types and the signs of CEM-BI-RADS was analyzed.Results A total of 220 patients with breast cancer were diagnosed,including 50 patients with Luminal A,128 patients with Luminal B,15 patients with HER2-enriched,and 27 patients with triple-negative.Among the clinicopathologic characteristics of different molecular subtypes of breast cancer,only the pathological type and molecular subtype of breast cancer had statistical significance(P=0.012).Invasive breast cancer was the main pathological type of the four molecular types of breast cancer,and there was no significant statistical significance between age,menopause and lymph node metastasis and molecular subtype of breast cancer(P>0.05).In low-energy maps,there were statistically significant differences in mass margins and mass with calcification among different molecular subtypes.Luminal A breast cancer tumor margins were mostly spiculated(64.0%,32/50),while other breast cancer molecular subtypes were mostly indistinct,and most HER2-enriched breast cancer tumors(66.7%,10/15)were mostly accompanied by calcification.In subtraction images,there were statistically significant differences between the margin,length diameter,internal enhancement and molecular classification of breast cancer.The maximum diameter of Luminal A and Luminal B breast cancers is less than 2.0 cm,while the maximum diameter of HER2-enriched and triple-negative breast cancers is 3.1-5.0 cm.In addition,although the edges of the four molecular subtypes of tumor enhancement were most common with obscured edges and the internal enhancement was uneven,compared with other molecular subtypes of breast cancer,the internal enhancement of some triple-negative breast cancer tumors showed circular enhancement(22.2%,6/27).Conclusion The imaging signs of different molecular subtypes of mass breast cancer in CEM have certain characteristics,which can provide important reference value in guiding the diagnosis,treatment and prognosis evaluation of breast cancer.
mass breast cancermolecular subtypecontrast-enhanced mammography
国家科技期刊平台
NSTL
万方数据
