Serum inflammatory indicators combined with enhanced CT image features can predict risk classification of gastrointestinal stromal tumors
Objective To investigate the correlation between preoperative serum inflammatory indicators combined with enhanced CT image features and the risk classification of gastrointestinal stromal tumor(GIST),and analyze its diagnostic efficacy for GIST risk classification.Methods A lot of 148 patients with pathologically confirmed GISTs were collected from March 2022 to March 2024 in Yancheng First People's Hospital and classified according to the National Institutes of Health revised criteria.Preoperative serum inflammatory indicators[neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),systemic immunoinflammatory index(SII)]and enhanced CT image features[tumor length,tumor location,enhancement pattern,shape,intratumor cystic or necrosis,calcification,surface ulcer]were retrospectively analyzed.These patients were divided into low risk group(n=73,very low risk,low risk)and high risk group(n=75,intermediate risk,high risk).The differences of relevant indicators between low and high risk groups were compared,and Spearman correlation was used to analyze the correlation between inflammatory indicators,enhanced CT image features and risk classification.Results NLR,PLR,SII,tumor length,tumor location,intratumoral cystic or necrosis,enhancement pattern,and shape were positively correlated with different risk classification.The optimal cut-off values for high risk group were NLR>2.285(AUC=0.741),PLR>167.135(AUC=0.654),SII>410.495(AUC=0.711),tumor length>4.65(AUC=0.931),the AUC of combining multi-indexes was 0.941,better than the above single index.Conclusion Preoperative serum inflammatory indicators combined with enhanced CT imaging features can better predict the risk classification of GIST,the combined diagnosis has the best efficiency,and provides reference for patients to make personalized plan.
国家科技期刊平台
NSTL
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