Prenatal ultrasound quantification combined with serum β-human chorionic gonadotropin,alpha fetoprotein and uncojugated estriol has high screening value for fetal facial deformities
Objective To investigate the value of prenatal ultrasound quantification combined with serum β-human chorionic gonadotropin(β-HCG),alpha fetoprotein(AFP)and uncojugated estriol(uE3)in screening fetal facial deformities.Methods A total of 123 pregnant women in the second trimester of pregnancy who received prenatal screening at the hospital from February 2021 to February 2024 were selected as the research subjects.All of them underwent ultrasound examination and detection of serum indexes.The outcomes of induced labor or pregnancy were used as the gold standard to analyze the diagnostic value of prenatal ultrasound quantitative parameters and serum indexes for fetal facial deformities.Results Among 123 pregnant women,71(57.72%)were found to have fetal facial deformities,and 52(42.28%)did not have any fetal facial deformities.They were included in the deformity group and the non-deformity group,respectively.Univariate analysis and multivariate logistic regression analysis results showed that fetal nuchal translucency(NT)thickness,and the levels of β-HCG,AFP and uE3 were risk factors for fetal facial deformities(P<0.05).61 cases and 56 cases of fetal facial deformities were diagnosed by NT and serum indexes,respectively.Combination of the two diagnosed 67 cases of fetal facial deformities.The diagnostic sensitivity,specificity,and accuracy of NT combined with serum indexes were higher than those of separate diagnosis.There was a statistically significant difference in sensitivity(P<0.05),but there was no statistically significant difference in specificity or accuracy(P>0.05).Conclusion Abnormal NT,and abnormal levels of β-HCG,AFP and uE3 all indicate a high risk of fetal facial deformities.The combination of prenatal ultrasound quantitative parameters and serum β-HCG,AFP and uE3 can significantly improve the sensitivity in detecting fetal facial deformities.It has relatively high clinical value in fetal facial deformities screening.
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