Uterine artery blood flow parameters combined with D-dimer in early pregnancy can effectively assess adverse pregnancy outcomes in pregnant women with recurrent miscarriage
Objective To investigate the value of uterine artery polyflow parameters combined with peripheral blood D-dimer(D-D)in the assessment of adverse pregnancy outcomes in pregnant women with recurrent miscarriage in early pregnancy.Methods Eighty cases of early pregnancy recurrent miscarriage admitted to Huai'an Maternal and Child Health Hospital from January 2021 to June 2023 were selected as the study group and followed up until 28 weeks of gestation,and they were categorized into the pregnancy loss group(n=35)and the pregnancy success group(n=45)according to the pregnancy outcome,and 92 pregnant women with normal pregnancies who underwent obstetric examination in the same period of time in the hospital were selected as the control group.The uterine artery early diastolic index(NI),resistance index(RI),ratio of maximum peak systolic flow rate to end-diastolic flow rate(S/D),pulsatility index(PI),and levels of peripheral blood D-D were compared between the study group and the control group,the pregnancy loss group and the pregnancy success group,and the pregnancy loss group was included as positive and the pregnancy success group was included as negative,and the predictive value of uterine artery NI,RI,S/D,PI,peripheral blood D-D single and combined tests for the diagnosis of adverse pregnancy outcomes in pregnant women with recurrent miscarriages in the early stages of pregnancy was analyzed by plotting the ROC curves.Results Uterine artery NI was lower in the study group than in the control group(P<0.05);uterine artery RI,S/D,PI and peripheral blood level of D-D were higher than in the control group(P<0.05).Uterine artery NI was lower in the pregnancy loss group than in the pregnancy success group(P<0.05);uterine artery RI,S/D,PI,and peripheral blood level of D-D were higher than those in the pregnancy success group(P<0.05).ROC curve analysis showed that the AUC value of the joint test for predicting adverse pregnancy outcomes in pregnant women with recurrent miscarriage in early pregnancy was higher than that of NI,RI,S/D,PI and peripheral blood D-D in a single test(P<0.05).Conclusion The combination of uterine artery multiflow parameters and peripheral blood D-D testing was more advantageous in predicting adverse pregnancy outcomes in women with recurrent miscarriages in early pregnancy,and the clinical follow-up could be carried out by means of the combination of uterine artery multiflow parameters and peripheral blood D-D testing for timely assessment of the adverse pregnancy outcomes of pregnant women with recurrent miscarriages,so as to promote the improvement of the pregnancy outcomes of pregnant women with recurrent miscarriages.
recurrent miscarriageearly pregnancypregnancy outcomeuterine arteryblood flow parametersD-dimerpredictive value
国家科技期刊平台
NSTL
万方数据
