血清D-D、PCT联合CRP检测在肺炎支原体肺炎患儿病情及预后评估中的作用
The role of serum D-D,PCT combined with CRP in the assessment of disease condition and prognosis of children with mycoplasma pneumoniae pneumonia
马慧 1林海庆 1李胡珺1
作者信息
- 1. 宣城市人民医院普儿科,安徽,宣城 242000
- 折叠
摘要
目的 分析血清D-二聚体(D-D)、降钙素原(PCT)联合C反应蛋白(CRP)检测在肺炎支原体肺炎(MPP)患儿病情及预后评估中的作用.方法 选取2021年9月至2022年5月宣城市人民医院收治的MPP患儿151例为研究对象,根据病情严重程度分为轻症组104例及重症组47例,比较不同病情严重程度患儿血清D-D、PCT及CRP水平.分析血清D-D、PCT及CRP水平与CPIS评分的相关性.比较不同预后患儿血清D-D、PCT及CRP水平,分析D-D、PCT及CRP单一、联合对MMP患儿预后的评估价值.结果 重症组血清D-D、PCT、CRP水平及CPIS评分均显著高于轻症组,差异具有统计学意义(P<0.05).血清D-D、PCT、CRP水平均与CPIS评分呈正相关(P<0.05).预后不良组血清D-D、PCT及CRP水平均显著高于预后良好组,差异具有统计学意义(P<0.05).ROC结果显示,D-D+PCT+ CRP检查灵敏度为 0.932,特异度为 0.901,AUC=0.856(95%CI:0.846～0.935),均高于D-D、PCT及CRP单一检查(P<0.05).结论 血清D-D、PCT及CRP与MPP病情进展存在密切联系,可作为预后评估的重要指标,三者联合更有利于判断MPP患儿的病情严重程度及预后情况.
Abstract
Objective To analyze the effects of serum D-dimer(D-D),procalcitonin(PCT)combined with C-reactive protein(CRP)in the assessment of disease condition and prognosis of children with mycoplasma pneumoniae pneumonia(MPP).Methods A total of 151 children with MPP admitted to Xu-ancheng People's Hospital from September 2021 to May 2022 were selected as the study objects and were di-vided into the mild group(104 cases)and the severe group(47 cases)according to the severity of the disease.The levels of serum D-D,PCT and CRP in children with different severity of the disease were compared.The correlation between serum D-D,PCT and CRP levels and CPIS score was analyzed.The levels of serum D-D,PCT and CRP in different prognosis of children were compared,and the value of single or combined D-D,PCT and CRP in the prognosis of MMP children was analyzed.Results The levels of D-D,PCT,CRP and CPIS in the severe group were significantly higher than those in the mild group,and the difference was statisti-cally significant(P<0.05).Serum D-D,PCT and CRP levels were positively correlated with CPIS score(P<0.05).Serum D-D,PCT and CRP levels in the poor prognosis group were significantly higher than those in the good prognosis group,and the difference was statistically significant(P<0.05).The ROC results showed that the sensitivity and specificity of D-D + PCT + CRP were 0.932 and 0.901 respectively,the AUC=0.856(95%CI:0.846～0.935),which was higher than that of D-D,PCT and CRP alone(P<0.05).Conclusion Serum D-D,PCT and CRP are closely related to the progression of MPP and can be used as important indica-tors for prognosis assessment.The combination of the three is more conducive to determining the severity and prognosis of children with MPP.
关键词
D-二聚体/PCT/CRP/肺炎支原体肺炎Key words
D-dimer/PCT/CRP/Mycoplasma pneumoniae pneumonia引用本文复制引用
基金项目
安徽省卫生健康科研项目(AHWJ2022c034)
出版年
2024
NETL
NSTL
维普
万方数据