急性心肌梗死患者PCI术前FDP水平对术中慢/无复流的预测价值
Predictive value of preoperative FDP level on slow/no reflow during PCI of patients with acute myocardial infarction
杨帆 1田富云 1孙君 1杨丽 1张莉1
作者信息
- 1. 郑州市第七人民医院检验科,河南,郑州 450000
- 折叠
摘要
目的 研究急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)前纤维蛋白原降解产物(FDP)水平对术中慢/无复流的预测价值.方法 选择2021年1月至2022年10月在郑州市第七人民医院接受急诊PCI的AMI患者作为研究对象,根据术中是否发生慢/无复流分为慢/无复流组和对照组,术前检测生化指标、FDP、D-二聚体(D-D)、白介素-6(IL-6)、白介素-17(IL-17).比较两组间各项指标的差异,采用logistic回归模型分析慢/无复流的影响因素,采用ROC曲线分析慢/无复流的预测指标.结果 慢/无复流组与对照组的各项生化指标比较差异无统计学意义(P>0.05);慢/无复流组的术前FDP、D-D、IL-6、IL-17均高于对照组,差异有统计学意义(t=7.468、6.070、16.668、8.182,P<0.05);慢/无复流组的术前FDP、D-D水平与IL-6、IL-17水平呈正相关(P<0.05);FDP、D-D、IL-6、IL-17均是发生慢/无复流的影响因素(P<0.05);FDP联合D-D对PCI术中慢/无复流具有良好的预测价值(P<0.05).结论 术前FDP升高与AMI患者急诊PCI术中发生慢/无复流相关,FDP联合D-D检测对慢/无复流具有预测价值.
Abstract
Objective To study the predictive value of preoperative fibrinogen degradation prod-uct(FDP)on slow/no reflow during percutaneous coronary intervention(PCI)of patients with acute myocar-dial infarction(AMI).Methods AMI patients who received emergency PCI in Zhengzhou Seventh People's Hospital from January 2021 to October 2022 were divided into the slow/no reflow group and the control group according to intraoperative slow/no reflow.Preoperative biochemical parameters,FDP,D-dimer(D-D),interleukin-6(IL-6),interleukin-17(IL-17)were detected,the differences of each indicator between the 2 groups were compared,the influencing factors of slow/no reflow were analyzed by the logistic regression model and the predictors of slow/no reflow were analyzed by the ROC curve.Results There was no signifi-cant difference in biochemical parameters between the slow/no reflow group and the control group(P>0.05).Preoperative FDP,D-D,IL-6 and IL-17 in the slow/no reflux group were higher than those in the control group(t=7.468,6.070,16.668,8.182,P<0.05).Preoperative FDP and D-D levels positively correlated with IL-6 and IL-17 in the slow/no reflow group(P<0.05).FDP,D-D,IL-6 and IL-17 were influencing factors of slow/no reflow(P<0.05).FDP and D-D had good predictive value of slow/no reflow during PCI(P<0.05).Conclusion The increased preoperative FDP is associated with slow/no reflow during emergency PCI of AMI patients,and FDP combined with D-D test has predictive value for slow/no reflow.
关键词
急性心肌梗死/经皮冠状动脉介入术/慢/无复流/纤维蛋白原降解产物/D-二聚体/预测Key words
Acute myocardial infarction/Percutaneous coronary intervention/Slow/no reflow/Fibrinogen degradation products/D-dimer/Prediction引用本文复制引用
基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20210743)
出版年
2024
NETL
NSTL
维普
万方数据