Relationship between serum IL-6,PCT,TNF-α and adverse pregnancy outcomes in pregnant women with GBS infection
Objective To analyze the relationship between serum interleukin-6(IL-6),procalci-tonin(PCT),tumor necrosis factor-α(TNF-α)and adverse pregnancy outcomes in pregnant women infected with Group B streptococcus(GBS).Methods 125 GBS infection-positive women who underwent Beijing Tiantan Hospital,Capital Medical University and gave birth in this court from May 2020 to March 2022 were selected as the research subjects(GBS group),another 100 healthy pregnant women admitted during the same period were selected as the control group.The serum IL-6,PCT,and TNF-α levels between the GBS group and the control group were compared.The pregnancy outcomes between the two groups were compared.The single factors that affected adverse pregnancy outcomes in pregnant women with GBS infection were analyzed.The multiple logistic regression was used to analyze the risk of adverse pregnancy outcomes in pregnant wom-en with GBS infection factor.Results The levels of IL-6,PCT,and TNF-α in the control group were lower than those in the GBS group(P<0.05).The incidence rates of premature birth,premature rupture of mem-branes,fetal distress,neonatal GBS infection and neonatal pathological jaundice in the control group were low-er than those in the GBS group(P<0.05).After inspection and follow-up,it was found that 37 women in the GBS group had adverse pregnancy outcomes and 88 women had normal pregnancy outcomes;there was no sta-tistically significant difference in the adverse pregnancy outcome group and the normal pregnancy outcome group in terms of gestational age,whether they were primipara,etc.(P>0.05).Comparing the age,GBS in-fection grade,serum IL-6,PCT,and TNF-α levels between the two groups showed statistically significant dif-ferences(P<0.05).Multiple logistic regression analysis showed that:age≥35 years old,the classification of GBS infection as GBS carrier or GBS chorioamnionitis,IL-6>0.463 ng/L,PCT≥0.5 ng/mL,and TNF-α≥30 fmol/mL were risk factors for adverse pregnancy outcomes in pregnant women with GBS infection(P<0.05).Conclusion Serum IL-6,PCT,and TNF-α levels are elevated in patients with adverse pregnancy out-comes in GBS-infected mothers.The three indicators can be used as important indicators for monitoring and preventing adverse pregnancy outcomes in GBS-infected mothers.
NETL
NSTL
万方数据
维普
