Correlation between APACHEⅡscore,lactic acid concentration,D-dimer and prognosis in patients with severe infection
Objective To explore the correlation between score of acute physiology and chronic health evaluationⅡ(APACHEⅡ),lactic acid concentration,D-dimer and prognosis in patients with severe infection.Methods A total of 81 patients with severe infection admitted to Critical Care Medicine Depart-ment of the hospital were enrolled as the observation group between January 2021 and December 2022.Accord-ing to 28 d prognosis,they were divided into the survival group(49 cases)and the death group(32 cases).The clinical characteristics,APACHEⅡscore,lactic acid concentration and D-dimer level were compared be-tween the observation group and the control group,as well as between the survival group and the death group.The relationship between APACHEⅡ score and lactic acid concentration,D-dimer was analyzed by Pearson correlation analysis.The risk factors of prognosis were analyzed by multivariate logistic stepwise regression analysis.The predictive value of APACHEⅡscore,lactic acid concentration and D-dimer for poor prognosis was analyzed by the receiver operating characteristic(ROC)curves.Results The APACHEⅡ score,lactic acid concentration and D-dimer level in the observation group were higher than those in the control group(t= 4.269,8.785,2.746,P<0.05).The proportion of mechanical ventilation,SOFA score,stay time in ICU and PCT level in the death group were higher than those in the survival group(χ2=4.847,4.940,8.256,12.474,P<0.05),the APACHEⅡscore,lactic acid and D-dimer in the death group were higher than those in the survival group(t=2.629,9.702,3.086,P<0.05).Pearson correlation analysis showed that the APACHEⅡscore was positively correlated with the lactic acid concentration and D-dimer level(P<0.05).Logistic regression analy-sis showed that mechanical ventilation,APACHEⅡscore≥22.28 points and lactic acid concentration≥3.58 mmol/L were independent risk factors of poor prognosis(P<0.0.5).The ROC curves analysis showed that the area under the curve(AUC)of the APACHEⅡscore combined with the lactic acid concentration and D-dimer for predicting poor prognosis was 0.921(P<0.05).Conclusion The APACHE II score,lactic acid concentra-tion and D-dimer are closely related to prognosis in patients with severe infection.Among them,the APACHEⅡscore and lactic acid concentration are risk factors affecting the prognosis in patients with severe infection.
Score of acute physiology and chronic health evaluationⅡLactic acidD-dimerSe-vere infection
NETL
NSTL
万方数据
维普
