Value of serum AFP,GP73 and GPC3 detection in the diagnosis and prognosis assessment of primary liver cancer
Objective To evaluate the value of serum alpha-fetoprotein(AFP),Golgi glycopro-tein 73(GP73)and phosphatidyl inositol proteoglycan 3(GPC3)detection in the diagnosis and prognosis of primary liver cancer.Methods 52 patients with primary liver cancer admitted to the First Affiliated Hospital of Zhengzhou University from May 2021 to May 2022 were selected as the study objects,another 46 cases with cirrhosis and 48 cases healthy physical examination admitted to our hospital during the same period were selected as the cirrhosis group and the health group,respectively.The levels of AFP,GP73 and GPC3 were compared among the three groups and the PHC group at different pathological stages;the general prognostic data of PHC and levels of AFP,GP73 and GPC3 were compared;Multiple logistic regression was used to ana-lyze the risk factors affecting the prognosis of PHC.The ROC curve was drawn to analyze the diagnostic effect of serum AFP,GP73 and GPC3 alone and combined detection of PHC.Results The levels of AFP,GP73 and GPC3 were as follows:PHC group>cirrhosis group>healthy group,the difference was statistically sig-nificant(P<0.05).AFP,GP73,GPC3 levels in the PHC group with different pathological stages were:Ⅳ>Ⅲ>Ⅱ>Ⅰ,the difference was statistically significant(P<0.05).There were 45 cases in the good prognosis group and 7 cases in the poor prognosis group.There was no significant difference in gender,age and BMI be-tween the two groups(P>0.05).The levels of prothrombin,red blood cell count,apolipoprotein A1,GGT,AFP,GP73 and GPC3 were significantly different between the two groups(P<0.05).Multiple logistic regres-sion analysis showed that the increased levels of prothrombin,red blood cell count,apolipoprotein A1,GGT,AFP,GP73 and GPC3 were risk factors for poor prognosis in PHC patients(P<0.05).The sensitivity and specificity of the combination of AFP,GP73 and GPC3 for diagnosis and prognosis of PHC were 0.956 and 0.857,respectively;The AUC=0.950(95%CI:0.909～0.991),which was significantly higher than AFP,GP73,GPC3 detection alone.Conclusion The combination of serum AFP,GP73 and GPC3 has a high clini-cal value in the diagnosis of PHC and can be used for the early diagnosis of PHC.The prognosis of patients with PHC can be evaluated by detecting the serum levels of the above indicators.
NETL
NSTL
万方数据
维普
