Effects of Lactobacillus live bacteria capsules combined with human interferon α-2b gel in the treatment of HR-HPV infection after CKC in HSIL patients and its influence on the levels of IL-4,IL-10 and TNF-α
Objective To explore the effects of Lactobacillus live bacteria capsules combined with human interferon α-2b gel in the treatment of high-risk human papillomavirus(HR-HPV)infection after cervical cold knife conization(CKC)in high-grade squamous intraepithelial lesions(HSIL)patients and its influence on interleukin 4(IL-4),interleukin 10(IL-10)and tumor necrosis factor-α(TNF-α)levels.Methods 161 patients with HR-HPV infection after CKC treatment for HSIL in Tongzhou District Maternal and Child Health Hospital of Beijing from January 2019 to December 2022 were selected as the study subjects,and according to the treatment method,they were divided into the control group of 79 patients(treated with human interferon α-2b gel)and the study group of 82 cases(treated with Lactobacillus live bacteria capsules combined with human interferon α-2b gel).The clinical efficacy,vaginal microecological score(Nugent),local microimmune status of the cervix[IL-4,IL-10,TNF-α,interleukin-2(IL-2),interferon-γ(IFN-γ)]level,positive expression rate of[indoleamine 2,3-dioxygenase(IDO),IL-10,IL-4,TNF-α]in cervical lesion tissue between the two groups were compared.Results After the treatment,the total effective rate in the control group was 83.54%,and that in the study group was 93.90%.The total effective rate in the control group was lower than that in the study group,the difference was statistically significant(P<0.05);the vaginal microecological environment restoration rate in the study group(92.68%)was higher than that in the study group(82.28%),and the pH value and Nugent score in the study group were lower than those in the control group,the difference was statistically significant(P<0.05).After the treatment,the levels of IL-2 and IFN-γ cytokines in the two groups increased,and the study group was higher than the control group;the levels of IL-4,IL-10,and TNF-α in the two groups decreased,and the study group was lower than the control group,the difference was statistically significant(P<0.05).The positive expression rates of IDO,IL-10,IL-4,and TNF-α in cervical lesions in the two groups were lower than those before treatment,and the study group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion The application of Lactobacillus live capsule combined with human interferon α-2b gel in the treatment of HSIL patients with CKC with HR-HPV infection after surgery is more effective,which is beneficial to maintaining a stable cervical microecological environment,improving immune regulation,and reducing inflammatory.
Lactobacillus live bacteria capsuleHuman interferon α-2b gelHSILCKCHR-HPVIL-4IL-10TNF-α
NETL
NSTL
万方数据
维普
