Clinical significance of TCT combined with HR-HPV gene detection in screening cervical cancer and precancerous lesions
Objective To investigate the clinical significance of ThinPrep cytologic test(TCT)and high-risk human papillomavirus(HR-HPV)gene detection in screening cervical cancer and precancerous lesions.Methods A total of 6,762 patients with cervical lesions underwent TCT and HR-HPV gene detec-tion at the gynecological outpatient department in the People's Hospital of Linxia from January 2020 to Decem-ber 2022 were selected.The patients with positive results of TCT and/or HR-HPV gene detection were subject-ed to colposcopy and histopathological examination.Based on these diagnostic criteria,the diagnostic value of TCT and HR-HPV gene detection alone and jointly in screening cervical cancer and precancerous lesions was analyzed.Results Of the 6,762 subjects,705 were positive for TCT(10.43%)and 884 were positive for HR-HPV gene detection(13.07%).1289 cases with positive TCT and/or HR-HPV Genetic testing were exam-ined by Colposcopy and histopathology.838 cases(65.01%)were positive,including 53.94%CIN1,21.48%CIN2,15.39%CIN3,and 9.19%cervical cancer.Taking the histopathological results as the gold standard for diagnosis,the pathological positive rates of TCT,HR-HPV Genetic testing and TCT+HR-HPV Genetic testing were 40.65%,49.50%and 54.38%,respectively.The pathological positive rate of TCT+HR-HPV Genetic test-ing was significantly higher than that of TCT alone and HR-HPV Genetic testing,with a statistically signifi-cant difference(χ2=48.730,6.168,P<0.05).The sensitivity and accuracy of TCT combined with HR-HPV gene detection in screening cervical cancer and precancerous lesions were 83.65%and 84.54%,which were higher than those of TCT(64.68%,70.75%)or HR-HPV gene detection(76.13%,78.28%)alone(χ2= 79.550,41.259,15.145,4.262,P<0.05).Conclusion TCT combined with HR-HPV gene detection can im-prove the early detection rate of cervical cancer and precancerous lesions.
NETL
NSTL
万方数据
维普
