Effects of NAC combined with budesonide,glycopyrronium bromide and formoterol fumarate on blood gas indexes in patients with acute exacerbation of COPD
Objective To explore the effects of N-acetylcysteine(NAC)combined with budesonide,glycopyrronium bromide and formoterol fumarate inhalation therapy on blood gas indexes,serum procalcitonin(PCT)and C-reactive protein(CRP)levels in patients with acute exacerbation of COPD.Meth-ods 90 patients with acute exacerbation of COPD who were admitted to the Department of Respiratory and Critical Care Medicine of Suixi County Hospital,Anhui Province from January 2022 to January 2023 were se-lected as the research subjects and were divided into the control group(45 cases)and the observation group(45 cases)according to the random number table method.Both groups were given routine symptomatic treat-ment,and the control group was additionally given budesonide,glycopyrronium bromide and formoterol fuma-rate inhalation aerosol treatment.Based on symptomatic treatment,the observation group was given NAC com-bined with budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol treatment.Blood gas indexes,serum PCT and CRP levels,lung function and treatment effective rate were compared between the two groups before and after treatment.Results The total effective rate of treatment in the observation group was 84.44%,which was 64.44%higher than that in the control group(χ2=4.731,P<0.05).The arterial partial pressure of oxygen(PaO2)and oxygen saturation(SaO2)in the observation group were higher than those in the control group while the arterial partial pressure of carbon dioxide(PaCO2)was lower than the control group(t=7.780,4.153,5.375,P<0.05).Serum PCT and CRP levels in the two groups of patients were re-duced compared with those before treatment,and the levels in the observation group were lower than those in the control group(t=10.733,8.326,P<0.05).The forced expiratory volume in first second(FEV1),the per-centage of forced expiratory volume in first second to predicted value(FEV1%pred),forced vital capacity(FVC)and peak expiratory flow(PEF)were higher in the observation group than those in the control group(t= 5.604,6.073,6.103,2.270,P<0.05).Conclusion NAC combined with budesonide,glycopyrronium bro-mide and formoterol fumarate inhalation therapy has a significant efficacy on patients with acute exacerbation of COPD,and it can reduce inflammatory response and improve lung function and has clinical application value.
N-acetylcysteineBudesonide,Glycopyrronium bromide and formoterol fumarateAcute exacerbation of chronic obstructive pulmonary diseaseBlood gas indexesLung function
NETL
NSTL
万方数据
维普
