Relationship between traditional Chinese medicine syndrome types of lung adenocarcino-ma and TGF-β,IFN-γ and MMP-9 in induced phlegm
Objective To observe the relationship between traditional Chinese medicine syndrome types of lung adenocarcinoma and transforming growth factor(TGF)-β,interferon(IFN)-γ and matrix metal-loproteinase-9(MMP-9)in induced phlegm.Methods Eighty patients with lung adenocarcinoma admitted to the hospital from January 2020 to January 2023 were selected as the study group.They were divided into group A(spleen-kidney yang deficiency pattern),group B(qi-yin deficiency pattern)and group C(spleen-lung qi deficiency pattern)based on TCM syndrome types.At the same time,80 healthy individuals were selected as the control group.The levels of TGF-β,IFN-γ and MMP-9 in induced sputum of different groups were com-paratively analyzed.Results Among the 80 patients with lung adenocarcinoma,there were 28(35.00%)cas-es of spleen-kidney yang deficiency pattern,26(32.50%)cases of qi-yin deficiency pattern and 26(32.50%)cases of spleen-lung qi deficiency pattern.The levels of TGF-β and MMP-9 in induced sputum in the study group were higher than those in the control group(t=5.793,20.727,P<0.05),and the level of IFN-γ was lower than that in the control group(t=6.511,P<0.05).The levels of TGF-β and MMP-9 in induced sputum in group A were higher than those in group B and group C(t=3.704,3.859、5.948,6.290,P<0.05).The lev-el of IFN-γ and KPS score were lower than those in group B and group C(t=9.391,8.982,2.748,2.282,P<0.05).There was no statistically significant difference in above-mentioned indicators between group B and group C(t=0.269,0.808,0.421,0.376,P>0.05).Pearson correlation analysis results showed that the levels of TGF-β and MMP-9 in induced sputum were negatively correlated with the KPS score(P<0.05),and the level of IFN-γ was positively correlated with the KPS score(P<0.05).Conclusion Compared with patients with qi-yin deficiency syndrome and spleen-lung qi deficiency syndrome,patients with spleen-kidney yang de-ficiency syndrome had higher levels of TGF-β and MMP-9,and lower IFN-γ level in induced sputum.The three indicators are correlated with the KPS score and can be used as auxiliary indicators for Traditional Chi-nese Medicine syndrome differentiation of lung adenocarcinoma.
Lung adenocarcinomaTraditional Chinese Medicine syndrome typeTransforming growth factor-βInterferon-γMatrix metalloproteinase 9
NETL
NSTL
万方数据
维普
