Predictive value of ultrasound images for HER-2 expression in patients with breast ductal carcinoma in situ
Objective To establish a prediction model based on the features of ultrasound imag-es,and to explore the value of this model in predicting the expression of human epidermal growth factor recep-tor 2(HER-2)in patients with ductal carcinoma in situ of the breast.Methods 126 patients with breast duc-tal carcinoma in situ who were treated at Tunchang County People's Hospital from October 2016 to June 2020 were selected as the research subjects.Ultrasound image characteristics were collected when the patients were admitted to the hospital,and HER-2 levels were collected 1 year after the patients were admitted to the hospi-tal.According to the HER-2 expression of the patients,they were divided into a positive group(67 cases)and a negative group(59 cases).The clinical data of the two groups of patients were compared.The logistic regres-sion equation was used to analyze the influencing factors of HER-2 expression in patients with breast ductal car-cinoma in situ.A prediction model based on ultrasound image features was constructed to analyze its value in predicting HER-2 expression in patients with breast ductal carcinoma in situ.Results Univariate analysis showed that there were significant differences in the proportion of breast ductal carcinoma in situ,irregular shape,unclear boundary,marginal burr,internal microcalcification and axillary lymph node metastasis in the positive group(χ2=3.002,5.911,4.456,2.363,8.374,10.730,P<0.05).Logistics analysis showed that high clinical stage breast ductal carcinoma in situ,edge burrs,internal microcalcifications,and axillary lymph node metastasis are influencing factors for HER-2 expression in patients with breast ductal carcinoma in situ(OR= 0.073,1.448,0.550,0.481,P<0.05).Nomogram analysis showed that the C-index of the prediction model for predicting HER-2 expression in patients with breast ductal carcinoma in situ was 0.732,and the calibration curve showed that the absolute error of the prediction probability was 0.042.Conclusion Marginal burrs,internal mi-crocalcification,high clinical stage breast ductal carcinoma in situ,and axillary lymph node metastasis are influ-ential factors affecting the expression of HER-2 in patients with ductal carcinoma in situ of the breast.The predic-tion model established based on this can predict ductal carcinoma in situ of HER-2 expression in patients.
Ultrasound image featuresDuctal carcinoma in situ of the breastHuman epidermal growth factor receptor 2
NETL
NSTL
万方数据
维普
