Effect of ulinastatin combined with subhypothermia on serum TLR4/NF-κB indicators in patients undergoing cardiopulmonary resuscitation
Objective To analyze the effects of ulinastatin combined with mild hypothermia on toll-like receptor 4/nuclear factor-KB(TLR4/NF-κB)indexes in patients with cardiopulmonary resuscitation(CPR).Methods A prospective study was conducted on 120 patients with coma after successful CPR treat-ment in Xi'an International Medical Center Hospital from June 2020 to June 2022.The patients were divided in-to four groups by simple random method,with 30 cases in each group.Group A received routine symptomatic support,Group B received routine + ulinastatin treatment,Group C received routine + mild hypothermia treat-ment,and Group D received routine + ulinastatin + mild hypothermia treatment.The inflammatory response,cardiac function,brain function,TLR4 and NF-κB levels before and after treatment among the four groups were compared.Results Compared with Group A,the levels of interleukin 6(IL-6),interleukin 8(IL-8),troponin(cTnI)and left ventricular end diastolic diameter(LVEDD)in Group B,Group C and Group D were significantly lower(P<0.05).The levels of left ventricular Ejection fraction(LVEF),Glasgow coma scale(GCS),comprehensive neurological score(NFCS),TLR4 and NF kB were significantly increased(P<0.05).Compared with Group D,the levels of IL-6,IL-8,cTNI,LVEDD,TLR4,and NF-κB in Group B and Group C increased with statistical significance(P<0.05),while LVEF,GCS scores,and NFCS scores de-creased with statistical significance(P<0.05).Conclusion Ulinastatin combined with mild hypothermia treat-ment can improve inflammatory response and exert protective effects on cardiac and brain function,which may be related to its negative feedback regulation of TLR4/NF-κB.
NETL
NSTL
万方数据
维普
