Application value of early detection of plasma miR-379,miR-195 and Gas6 levels in patients with AMI
Objective To analyze the application value of early detection of plasma microRNA-379(miR-379),microRNA-195(miR-195)and growth arrest specific protein 6(Gas6)levels in patients with acute myocardial infarction(AMI).Methods 265 patients who were hospitalized in the Department of Cardi-ology,Beijing Shijitan Hospital Affiliated to Capital Medical University were selected between May 2021 and July 2022,and were classified into the AMI group(n=127)and the non-AMI group(n=138).120 healthy subjects with physical examination during the same period were selected as the control group.The expression levels of plasma miR-379 and miR-195 and Gas6 at admission were compared among the three groups.Pearson correlation coefficient analysis was used to analyze the relationship between plasma Gas6 level and expression levels of miR-379 and miR-195 in patients with AMI at admission.The diagnostic value of plasma Gas6 level and expression levels of miR-379 and miR-195 at admission on early AMI was analyzed by the receiver operat-ing characteristic curve(ROC).Results There were statistically significant differences in the plasma levels of miR-379,miR-195,and Gas6 among the three groups at enrollment(P<0.05).Comparison of plasmamiR-379 levels:AMI group<non-AMI group<control group(P<0.05).Comparison of miR-195 and Gas6 levels:AMI group>non-AMI group>control group(P<0.05).Pearson correlation coefficient analysis showed that Gas6 was negatively correlated with the level of miR-379(P<0.05)and positively correlated with the level of miR-195(P<0.05).The ROC results showed that plasma miR-379,miR-195and Gas6 alone had certain limitations in diagnos-ing early AMI(AUC=0.808,0.718 and 0.752),and the combination of the three had better efficiency(AUC= 0.879).Conclusion The levels of plasmamiR-379,miR-195and Gas6 are abnormally expressed in patients with AMI,and these three indicators can be used as reference indicators for the early diagnosis of AMI.
Plasma microRNA-379MicroRNA-195Growth arrest specific protein 6Acute myocardial infarction
NETL
NSTL
万方数据
维普
