Relationship between serum lncRNA p21 expression level and prognosis of patients with acute myocardial infarction treated with PCI
Objective To investigate the relationship between serum lncRNA p21 expression level and prognosis of patients with acute myocardial infarction treated with percutaneous coronary intervention(PCI).Methods A total of 102 patients with acute myocardial infarction treated with PCI in Shuyang County Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected.The patients were followed up for 1 year after surgery.According to acute physiology and chronic health evaluation(APACHE-Ⅱ),patients were divided into the good prognosis group and the poor prognosis group,with the good prognosis group of 72 cases and the poor prognosis group of 30 cases.General clinical data such as gen-der,body mass index(BMI)and hypertension were compared between the two groups.The levels of troponin(cTnl)and creatine kinase isoenzyme(CK-MB)on admission and the expression of serum lncRNA p21 before and after treatment were compared between the two groups,and the relationship between serum lncRNA p21 expression and patient prognosis was analyzed.Results The percentage of patients in the good prognosis group with chronic obstructive pulmonary disease(COPD),early coronary heart disease,and autoimmune dis-ease combination was lower than that in the poor prognosis group,with a statistically significant difference(P<0.05).The cTnl and CK-MB levels on admission were lower than those in the poor prognosis group,with a sta-tistically significant difference(P<0.05).Before treatment,the expression level of lncRNA p21 in the group with good prognosis was higher than that in the group with poor prognosis.After treatment,the expression level of lncRNA p21 in both groups increased and the group with good prognosis was higher than that in the group with poor prognosis.The difference was statistically significant(P<0.05).Logistic regression analysis results showed that the expression of high-level lncRNA p21 to glycolytic enzyme ratio(lncRNA p21/GAPDH)is a pro-tective factor for the prognosis of patients with acute myocardial infarction treated with PCI.The prognosis is>60 years old,combined with COPD,premature coronary heart disease,and combined Autoimmune diseases and high levels of CK-MB are risk factors for the prognosis of patients with acute myocardial infarction treated with PCI(P<0.05).Conclusion The low expression of lncRNA-p21 can aggravate the damage to cardiomyo-cytes and endothelial cells.Endothelial cell injury may aggravate coronary stenosis,which is not conducive to the prognosis of patients with AMI.High serum lncRNA p21 expression level is a protective factor for the prog-nosis of AMI treated with PCI.
NETL
NSTL
万方数据
维普
