Significance of high-risk HPV classification combined with cervical secretions PKM2 and Stat3 in cervical cancer screening
Objective To explore the significance of high-risk human papillomavirus(HPV)clas-sification combined with cervical secretion pyruvate kinase M2(PKM2)and signal transduction and activator of transcription 3(Stat3)in cervical cancer screening.Methods 406 patients who were screened for cervical cancer in Nanyang Central Hospital of Henan Province from January 2019 to January 2021 were selected as the research objects.According to the pathological results,they were divided into the cervical cancer group(n= 136)and the non-cervical cancer group(n=270).Two groups of clinical data were collected to analyze the re-lated influencing factors of cervical cancer and the screening value of each indicator.Results Of the 406 pa-tients who received cervical cancer screening,208 had normal pathological results,22 cases of cervical in-traepithelial neoplasia,21 cases of cervical intraepithelial neoplasia,155 cases of cervical intraepithelial neo-plasia,19 cases of cervical intraepithelial neoplasia,gradeⅢ,and 136 cases of cervical cancer.Univariate analysis showed that the history of familial gynecological cancer,the number of sexual partners other than spouse/boyfriend,vaginal cleanliness,high-risk HPV typing,PKM2,and Stat3 were related to the occurrence of cervical cancer(P<0.05).Logistic multivariate Regression analysis,after controlling the family history of gynecological tumors,the number of sexual relations except spouse/boyfriend,and the cleanliness of the vagi-na,the high-risk HPV type positivity,PKM2≥the mean of both groups,and Stat3≥the mean of both groups were cervical Related independent risk factors for cancer(P<0.05).The ROC analysis showed that the AUC of high-risk HPV typing combined with cervical secretion PKM2 and Stat3 for cervical cancer screening was greater than any single indicator.Conclusion High-risk HPV typing positivity,cervical secretion PKM2>39.33 U/mL,and Stat3>0.07 ng/mL are independent risk factors related to cervical cancer.The combined de-tection of the three can provide a certain reference for clinical screening of high-risk groups for cervical can-cer,thereby improving patient outcomes.