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高危型HPV分型联合宫颈分泌物PKM2、Stat3在宫颈癌筛查中的意义

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目的 探讨高危型人乳头瘤病毒(HPV)分型联合宫颈分泌物丙酮酸激酶M2 型(PKM2)、信号传导与转录激活因子3(Stat3)在宫颈癌筛查中的意义.方法 选取2019年1月至2021年1月406例在河南省南阳市中心医院接受宫颈癌筛查者作为研究对象,根据病理结果分为宫颈癌组(n=136)、非宫颈癌组(n=270),收集两组临床资料,分析宫颈癌的相关影响因素及各指标的筛查价值.结果 406例接受宫颈癌筛查者,病理结果正常208例,宫颈上皮内瘤变Ⅰ级22例,宫颈上皮内瘤变Ⅱ级21例,宫颈上皮内瘤变Ⅲ级19例,宫颈癌136例.单因素分析,家族性妇科肿瘤史、除配偶/男朋友外性关系对象数量、阴道清洁度、高危型HPV分型情况、PKM2、Stat3与宫颈癌的发生有关(P<0.05);Logistic多因素回归分析,将家族性妇科肿瘤史、除配偶/男朋友外性关系对象数量、阴道清洁度控制后,高危型HPV分型阳性、PKM2≥两组均值、Stat3≥两组均值是宫颈癌发生的相关独立危险因素(P<0.05);ROC分析,高危型HPV分型联合宫颈分泌物PKM2、Stat3 筛查宫颈癌的AUC大于任一单一指标(P<0.05).结论 高危型HPV分型阳性、宫颈分泌物PKM2>39.33 U/mL、Stat3>0.07 ng/mL是宫颈癌相关独立危险因素,联合检测三者能为临床筛查宫颈癌高风险人群提供一定参考,从而改善患者预后.
Significance of high-risk HPV classification combined with cervical secretions PKM2 and Stat3 in cervical cancer screening
Objective To explore the significance of high-risk human papillomavirus(HPV)clas-sification combined with cervical secretion pyruvate kinase M2(PKM2)and signal transduction and activator of transcription 3(Stat3)in cervical cancer screening.Methods 406 patients who were screened for cervical cancer in Nanyang Central Hospital of Henan Province from January 2019 to January 2021 were selected as the research objects.According to the pathological results,they were divided into the cervical cancer group(n= 136)and the non-cervical cancer group(n=270).Two groups of clinical data were collected to analyze the re-lated influencing factors of cervical cancer and the screening value of each indicator.Results Of the 406 pa-tients who received cervical cancer screening,208 had normal pathological results,22 cases of cervical in-traepithelial neoplasia,21 cases of cervical intraepithelial neoplasia,155 cases of cervical intraepithelial neo-plasia,19 cases of cervical intraepithelial neoplasia,gradeⅢ,and 136 cases of cervical cancer.Univariate analysis showed that the history of familial gynecological cancer,the number of sexual partners other than spouse/boyfriend,vaginal cleanliness,high-risk HPV typing,PKM2,and Stat3 were related to the occurrence of cervical cancer(P<0.05).Logistic multivariate Regression analysis,after controlling the family history of gynecological tumors,the number of sexual relations except spouse/boyfriend,and the cleanliness of the vagi-na,the high-risk HPV type positivity,PKM2≥the mean of both groups,and Stat3≥the mean of both groups were cervical Related independent risk factors for cancer(P<0.05).The ROC analysis showed that the AUC of high-risk HPV typing combined with cervical secretion PKM2 and Stat3 for cervical cancer screening was greater than any single indicator.Conclusion High-risk HPV typing positivity,cervical secretion PKM2>39.33 U/mL,and Stat3>0.07 ng/mL are independent risk factors related to cervical cancer.The combined de-tection of the three can provide a certain reference for clinical screening of high-risk groups for cervical can-cer,thereby improving patient outcomes.

High-risk HPVPKM2Stat3Cervical cancer

叶永生、徐燕、孙君华、倪鸣

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河南省南阳市中心医院妇三科,河南,南阳 473000

高危型HPV PKM2 Stat3 宫颈癌

河南省科技厅项目

20220547X

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(1)
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