Correlation between serum DBP and 25(OH)D expression in late pregnancy and neona-tal eczema
Objective To analyze the correlation between the expression levels of serum vitamin D-binding protein(DBP),25-hydroxyvitamin D[25(OH)D]and neonatal eczema.Methods Clinical data of pregnant women and newborns delivered from the First Hospital of Qinhuangdao City from January 2018 to December 2019 were retrospectively analyzed.48 neonates with eczema were selected to be included in the ec-zema group,and 48 healthy neonates without eczema were selected to be included in the healthy group.Serum DBP and 25(OH)D expression levels of neonatal mothers in the late pregnancy of neonatal mothers were compared between the two groups.Binary logistic regression was used to analyze the influencing factors of neo-natal eczema.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of maternal serum 25(OH)D and DBP expression levels in late pregnancy for neonatal eczema,and the area un-der the curve(AUC),confidence interval,sensitivity,and specificity were obtained.The spearman method was used to analyze the correlation between maternal serum DBP and 25(OH)D expression levels in late preg-nancy and the occurrence of neonatal eczema.Results The expression levels of DBP and 25(OH)D in se-rum of mothers in the eczema group were lower than those in the healthy group,with statistical significance(P<0.05).The AUC of serum 25(OH)D and DBP in neonatal eczema were 0.908 and 0.884(P<0.05),re-spectively.Low levels of DBP and 25(OH)D in maternal serum during the third trimester were risk factors for neonatal eczema(P<0.05).The expression levels of DBP and 25(OH)D in maternal serum during late pregnancy were negatively correlated with the development of neonatal eczema(r=-0.665,-0.707,P<0.05).Conclusion The expression levels of maternal serum DBP and 25(OH)D in late pregnancy are correlated with the occurrence of neonatal eczema,the risk of neonatal eczema increases with the decrease in maternal se-rum DBP and 25(OH)D expression levels in late pregnancy,therefore,full attention should be paid to vita-min D supplementation for pregnant women to ensure adequate vitamin D nutrition for pregnant women and fe-tuses to effectively prevent the incidence of neonatal eczema.
Late pregnancyVitamin DNeonatal eczemaVitamin D binding protein25-hy-droxyvitamin D
NETL
NSTL
万方数据
维普
