Effects of different doses of dexmedetomidine on pain factors,inflammatory factors and cognitive function in patients undergoing laparoscopic myomectomy
Objective To investigate the effects of different doses of dexmedetomidine on pain factors,inflammatory response and cognitive function in patients undergoing laparoscopic myomectomy(LM).Methods A total of 98 patients with uterine fibroids who underwent LM in Xinxiang Central Hospital from March 2020 to March 2022 were selected as the research objects.They were divided into the low-dose group(n=32),the high-dose group(n=32)and the control group(n=34)by random number table method.The control group was treated with routine general anesthesia,and the low and high dose groups were treated with 0.1 and 0.5 μg/(kg·h)dexmedetomidine respectively based on the control group until the end of the oper-ation.The pain factors[β-endorphin(β-EP),norepinephrine(NE),P-substance(SP)],inflammatory fac-tors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and cognitive func-tion[assessed by mini-mental state examination(MMSE)]were compared among the three groups before op-eration and 1 and 3 days after operation.The incidence of postoperative adverse reactions was compared among the three groups.Results The comparison of β-EP,NE,SP,IL-6,TNF-α and CRP levels among the three groups 1 day after surgery was:high-dose group<low-dose group<control group,and the differences were sta-tistically significant(F=9.132,14.376,62.570,42.254,37.120,36.830,P<0.05).The comparison of β-EP,NE,SP,IL-6,TNF-α and CRP levels among the three groups on the 3rd day after surgery was as fol-lows:high-dose group<low-dose group<control group,and the differences were all statistically significant(F=8.903,10.280,73.878,19.720,29.216,46.666,P<0.05).The comparison of MMSE scale scores on the first day after operation was:high-dose group>low-dose group>control group,and the difference was sta-tistically significant(F=81.318,17.564,P<0.05).The comparison of MMSE scale scores on the 3rd day after operation was as follows:high-dose group>low-dose group>control group,and the difference was statistical-ly significant(F=17.564,P<0.05).Conclusion Dexmedetomidine at a dose of 0.5 μg/kg can reduce pain and inhibit the inflammatory response in LM patients,promote the recovery of postoperative cognitive function.
DexmedetomidineLaparoscopic myomectomyPain factorInflammatory reactionCognitive function
NETL
NSTL
万方数据
维普
