Efficacy of Jinghua Weikang Capsule in the treatment of chronic atrophic gastritis and its effect on inflammation and pyroptosis mediated by the NLRP3 pathway
Objective To study the therapeutic efficacy of Jinghua Weikang capsule on chronic atro-phic gastritis and its effect on NOD-like protein receptor 3(NLRP3)pathway mediated inflammation and pyropto-sis.Methods Patients with chronic atrophic gastritis admitted to the Department of Gastroenterology of Shoux-ian People's Hospital from January 2021 to March 2022 were selected for the prospective study and were divided into the observation group(n=58)receiving Jinghua Weikang capsule combined with Western medicine and the control group(n=57)receiving Western medicine by random number table.After 4 courses of treatment,the ther-apeutic effect,TCM syndrome score and gastric mucosa pathological score were evaluated,and the mRNA ex-pression levels of NLRP3 and Caspase-1 in gastric mucosa and the levels of IL-1β,IL-18 and GSDMD in serum were detected.Results The effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the TCM syndrome integral of gastric pain,gas-tric fullness,belching pantothenic acid,eating less and tolerating poor,the pathological scores of glandular atro-phy,intestinal metaplasia,dysplasia,the mRNA expression levels of NLRP3 and Caspase-1 in gastric mucosa,and serum levels of IL-1β,IL-18 and GSDMD were lower than those before treatment in two groups and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Jinghua Weikang capsule treatment can improve the therapeutic effect of chronic atrophic gastritis,improve traditional Chinese medicine syndrome and pathological changes of gastric mucosa,and inhibiting inflammation and pyroptosis mediated by the NLRP3 pathway may be the related molecular mechanism.
Chronic atrophic gastritisJinghua Weikang capsuleNod-like protein receptor 3In-flammation
NETL
NSTL
万方数据
维普
