Effect of PTED treatment on IL-6,HMGB-1 and IL-17 levels in lumbar disc herniation
Objective To explore the effects of percutaneous transforaminal endoscopic discecto-my(PTED)treatment on interleukin-6(IL-6),interleukin-17(IL-17)and high mobility group protein-1(HMGB-1)levels in lumbar disc herniation.Methods 122 patients with lumbar disc herniation admitted to the First Central Hospital of Baoding City from April 2019 to August 2022 were selected as the research sub-jects,according to the different treatment plan,they were divided into the TLIF group(n=58,Transforaminal lumbar interbody fusion(TLIF)treatment)and the PTED group(n=64,PTED treatment),IL-6,HMGB-1,and IL-17 levels between the two groups were compared,IL-6,HMGB-1,and IL-17 levels in the PTED group with different clinical and pathological characteristics were analyzed,and the multiple logistic regression analysis was used to analyze the risk factors affecting IL-6,HMGB-1,and IL-17 levels in the PTED group,the clinical efficacy and complications of the two groups were compared.Results The total effective rate of the PTED group(98.44%)was higher than that of the TLIF group(87.93%),and the difference was statisti-cally significant(P<0.05).The levels of IL-6,IL-17 and HMGB-1 in the PTED group were lower than those in the TLIF group,and the difference was statistically significant(P<0.05).There were statistically significant differences between the levels of IL-6,IL-17,and HMGB-1 in different ages,presence of diabetes,the length of operation time,smoking status,malnutrition,and low immune function subgroups of the PTED group(P<0.05).There was no statistically significant difference in the levels of IL-6,IL-17,and HMGB-1 between dif-ferent genders,different BMIs,intraoperative blood loss,and the usage of internal fixation subgroups(P>0.05).Multiple logistic regression analysis showed that,age>60 years,operation time>3 hours,malnutri-tion,diabetes,low immune function,and smoking were risk factors affecting IL-6,IL-17,and HMGB-1 lev-els in the PTED group(P<0.05).The total incidence of complications in the PTED group was lower than that of the TLIF group,and the difference was statistically significant(P<0.05).Conclusion PTED treatment can significantly reduce the levels of IL-6,HMGB-1 and IL-17 in patients with lumbar disc herniation,and the sur-gical effect is accurate;however,age,operation time,malnutrition,diabetes,low immune function,and smoking are factors that affect IL-6,HMGB-1,and IL-17 levels in lumbar disc herniation by PTED treatment.
NETL
NSTL
万方数据
维普
