Effects of alendronate sodium adjuvant PVP therapy on BALP,PTH and N-MID-OT lev-els in elderly patients with osteoporotic compression fractures
Objective To analyze the effects of alendronate-assisted percutaneous vertebroplasty(PVP)in the treatment of osteoporotic compression fractures in elderly patients on bone alkaline phasphatase(BALP),parathyroid hormone(PTH)and N-end middle Osteocalcin(N-MID-OT)levels.Methods 107 el-derly patients with osteoporotic compression fracture treated in Fenggrun District People's Hospital of Tang-shan City from January 2019 to February 2022 were selected and divided into an observation group and a con-trol group according to different treatment methods,the control group was treated with PVP(n=52),the ob-servation group took alendronate sodium as auxiliary PVP treatment(n=55).The Oswestry Disability Index questionnaire(ODI),visual analogue scale(VAS),bone metabolism indicators(BALP,PTH,N-MID-OT levels),adverse reactions and the incidence of refracture between the two groups were compared.Results The ODI scores of both groups decreased at 2 months,6 months,and 12 months after operation,and the ODI scores of the observation group were lower than those of the control group at all time periods after surgery,the difference was statistically significant(P<0.05).The VAS scores of both groups decreased at 2 months,6 months,and 12 months after surgery,and the VAS scores of the observation group were lower than those of the control group at all time periods after surgery,the difference was statistically significant(P<0.05).The levels of BALP,PTH and N-MID-OT in both groups decreased after operation,and the levels of BALP,PTH and N-MID-OT in the observation group were lower than those in the control group,the difference was statistically signifi-cant(P<0.05).Comparing the total incidence of adverse reactions between the two groups,the difference was not statistically significant,the difference was statistically significant(P>0.05),but the incidence of re-fracture in the observation group(7.28%)was significantly lower than that in the control group(25.00%),the difference was statistically significant(P<0.05).Conclusion Alendronate sodium adjuvant PVP therapy can effectively improve the vertebral function of elderly patients with osteoporotic compression fractures,reduce their pain,im-prove the levels of BALP,PTH and N-MID-OT in patients,and promote their postoperative recovery.
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NSTL
万方数据
维普
