Correlation between postoperative serum MMIF,IL-6 and PTH levels and postoperative hypoparathyroidism after papillary thyroid cancer surgery
Objective To analyze the correlation between serum levels of macrophage movement inhibitory factor(MMIF),interleukin-6(IL-6)and parathyroid hormone(PTH)levels with hypoparathyroidism after surgery for papillary thyroid cancer.Methods 134 patients diagnosed with papillary thyroid carcinoma in our hospital and underwent total thyroidectomy and central cervical lymph node dissection from June 2020 to April 2022 were selected as the study objects.The incidence of postoperative hypoparathyroidism was analyzed.Single factors affecting patients with hypoparathyroidism were analyzed,and multiple Logistic regression was used to analyze the risk factors affecting hypoparathyroidism.Pearson correlation coefficient was used to analyze the correlation between serum MMIF,IL-6,PTH after surgery and hypoparathyroidism.Results Among the 134 patients,112(83.58%)had normal parathyroid function,and 22(16.42%)had hypoparathyroid function after surgery.There was no significant difference in age,sex and tumor diameter between the two groups(P>0.05).There were significant differences in tumor location,central lymph node dissection location and number,combined Hashimoto thyroiditis and postoperative serum MMIF,IL-6 and PTH levels between the two groups(P<0.05).Multiple Logistic regression analysis showed that the tumor was in the dorsal membrane,combined with Hashimoto thyroiditis combined with postoperative serum MMIF≥2 ng/mL,IL-6>10.0 pg/L,PTH≥15 pg/mL were the risk factors affecting hypoparathyro-idism(P<0.05).According to Pearson correlation analysis showed that serum MMIF,IL-6 and PTH levels were positively correlated with hypoparathyroidism(P<0.05).Conclusion The level of serum MMIF,IL-6 and PTH can be used to predict whether the parathyroid function is decreased after the operation of papillary thyroid cancer,which provides a reliable basis for clinical treatment.
NETL
NSTL
万方数据
维普
