Changes of ESR,PCT and IL-8 and value of combined detection in patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To explore the changes of erythrocyte sedimentation rate(ESR),procalcito-nin(PCT)and interleukin-8(IL-8)and the value of combined detection in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 78 patients with AECOPD in Tian-chang Hospital of Traditional Chinese Medicine People's Hospital were enrolled as research subjects between May 2018 and July 2021.According to the severity of AECOPD,they were divided into the mild group(with-out respiratory failure,31 cases),the moderate group(acute respiratory failure-no life-threatening,28 cases)and the severe group(acute respiratory failure-life-threatening,19 cases).The levels of ESR,PCT and IL-8 among the three groups were compared,and their correlation with disease severity was analyzed.All patients were given symptomatic treatment.According to therapeutic efficacy,the patients were divided into the effec-tive group and the ineffective group.The evaluated value of combined detection with different indicators for disease severity and clinical efficacy was analyzed.Results With the aggravation of the disease,levels of ESR,PCT and IL-8 were increased in AECOPD patients,and the levels were shown as severe group>moder-ate group>mild group(F=100.904,163.469,45.916,P<0.05).The levels of ESR,PCT and IL-8 were posi-tively correlated with the severity of AECOPD(r=0.404,0.381,0.295,P<0.05).The levels of ESR,PCT and IL-8 in the ineffective group were higher than those in the effective group(t=4.961,7.892,6.535,P<0.05).The AUC of combined detection for evaluating the severity of AECOPD was greater than that of IL-8 alone,and the AUC for evaluating the severity of AECOPD was greater than that of ESR alone(P<0.05).Conclusion The levels of ESR,PCT and IL-8 are related to disease severity in AECOPD patients,and they have evaluated value on disease severity and therapeutic efficacy.
NETL
NSTL
万方数据
维普
