Expression and clinical significance of NLRP3,SAA and NFκB in serum of patients with craniocerebral infection after craniocerebral injury
Objective To study expression and clinical significance of NOD-like receptor protein 3(NLRP3),Amyloid A(SAA)and Nuclear Transcription factor(NF-κB)in serum of patients with cranioce-rebral infection after craniocerebral injury.Methods 70 patients with craniocerebral injury admitted to the People's Hospital of Rugao City,Jiangsu Province from June 2020 to June 2022 were selected as the study sub-jects.They were divided into an infected group(n=19)based on their infection status,and an uninfected group(n=51)as the control group.Serum NLRP3,SAA,and NF were analyzed κ The diagnostic value of B in postoperative craniocerebral infection after craniocerebral injury surgery.Results The levels of NLRP3,SAA and NFκB in infected group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).NLRP3,SAA and NFκB levels were statistically significant in patients with mild infection<moderate infection<severe infection(P<0.05).The levels of NLRP3,SAA and NFκB in poor prognosis group were significantly higher than those in good prognosis group,and the difference was sta-tistically significant(P<0.05).ROC results showed that the AUC of serum NLRP3 was 0.634,the sensitivity was 63.43%,the specificity was 67.40%,and the cut-off value was 114.02 pg/mL.The AUC of serum SAA for predicting craniocerebral infection after craniocerebral injury was 0.715,the sensitivity was 73.50%,the speci-ficity was 69.00%and the cut-off value was 30.99 mg/L.The AUC of serum NFκB for predicting craniocerebral infection after craniocerebral injury was 0.914,the sensitivity was 81.40%,the specificity was 70.00%,and the truncation value was 38.27 μg/mL.The specificity and accuracy of combined detection were higher than that of single detection(P<0.05).Conclusion Serum NLRP3,SAA and NFκB are all abnormally high in patients with craniocerebral infection after craniocerebral injury,and the combined detection of craniocerebral infection after craniocerebral injury has higher diagnostic efficacy.This study also provides a new idea for the clinical treatment of craniocerebral infection after craniocerebral injury,and has high clinical application value.
NOD-like receptor protein 3Amyloid ANuclear transcription factorCraniocere-bral injuryBrain infection
NETL
NSTL
万方数据
维普
