Mechanism and research progress of tRNA-derived fragment(tRF)in tumor invasion and metastasis
Transfer RNA-derived fragments (tRFs),also known as tRNA-derived small RNAs (tsRNAs),are a class of emerging regulatory non-coding RNAs. They are formed through specific cleavage of pre-tRNA or mature tRNA under certain conditions. TRFs have been found to have various unique biological functions in the development of tumors and other diseases. These functions include miRNA-like activities,regulation of gene expression by RNA-binding proteins(RBPs),protein translation,epigenetic regulation,and regulation of the cell cycle. In recent years,multiple studies have shown that tRFs are abnormally expressed and involved in the development of various tumors. These tumors include breast cancer,gastric cancer,colorectal cancer,liver cancer,lung cancer,prostate cancer,and leukemia. This article aims to summarize ther classification,biogene-sis,mechanisms of action,and biological significance of tRFs in tumor invasion and metastasis. By providing new insights,it may contribute to the discovery of novel diagnostic markers and therapeutic targets for tumors.
Transfer RNAtRNA-derived fragmentsTumorInvasion and metastasis
万方数据
维普
