Effects of hyperbaric oxygen-assisted antivenin on the swelling of affected limbs,changes of myocardial enzyme spectrum and inflammatory factors in patients with early belly viper bite poisoning
Objective To explore the effects of hyperbaric oxygen-assisted antivenin on swelling of affected limbs,changes of myocardial enzymes and inflammatory factors in patients with early belly snake bite poisoning. Methods A total of 83 patients with early belly snake bite poisoning undergoing emergency treatment at Ziyang First People's Hospital were enrolled as the research subjects between May 2021 and January 2023. They were divided into two groups:an observation group(n=41)and a control group(n=42)using the random number table method. The control group reveived treatment with antivenin ,while the observation group received additional treatment with hyperbaric oxygen. The clinical effectiveness ,time for swelling and pain to disappear,and length of hospitalization were observed in both groups. The changes in swelling of affected limbs,scores on the visual analogue scale(VAS),myocardial enzymes[creatine kinase(CK),creatine kinase isoenzyme MB(CK-MB),cardiac troponin I(cTnI)]and inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)]before and after treatment were compared between the two groups. Results Before treatment,there were no significant differences in swelling of affected limbs, VAS score,CK,CK-MB,cTnI,CRP,IL-6 or PCT between the two groups(P>0.05). After treatment,the overall response rate of the observation group was higher than that of the control group(97.56％ vs 83.33％, x2=4.822,P<0.05). The disappearance time of swelling and pain,as well as the hospitalization time were shorter in the observation group compared to the control group(t=7.058,7.618,11.170,P<0.05). The circumference of limbs in the observation group was shorter than that in the control group ,and the VAS score was lower than that in the control group(t=14.397,6.791,P<0.05). The levels of serum CK,CK-MB and cTnI in the observation group were lower than those in the control group(t=16.524,4.734,5.740,P<0.05), and the levels of CRP,IL-6 and PCT were also lower than those in the control group(t=4.945,4.999,6.591, P<0.05). Conclusion Hyperbaric oxygen-assisted antivenin can alleviate swelling of affected limbs ,reduce myocardial injury,inhibit the inflammatory response and effectively improve the clinical curative effect in patients with early belly snake bite poisoning.
万方数据
维普
