Relationship between miR-124,miR-210 and carotid stenosis in patients with non-cardiogenic cerebral infarction
Objective To explore the relationship between miR-124,miR-210 and carotid stenosis in patients with non-cardiogenic cerebral infarction. Methods A total of 124 patients with non-cardiogenic cerebral infarction were admitted to the Second Affiliated Hospital of Chengdu Medical College 416th Hospital of Nuclear Industry were enrolled between January 2021 and December 2022. They were divided into two groups based on the presence or absence of carotid stenosis:the stenosis group(n=64)and the non-stenosis group(n=60). The levels of serum miR-124,miR-210,hypersensitive C-reactive protein(hs-CRP)and homocysteine (Hcy) were measured and compared between the two groups. Furthermore,within the stenosis group,the patients were further divided into mild,moderate,and severe stenosis groups based on the severity of carotid stenosis. Differences in the levels of serum miR-124,miR-210,hs-CRP and Hcy among patients with different degrees of stenosis severity were compared. Additionally ,the correlation between serum miR-124,miR-210,hs-CRP,Hcy,and the severity of stenosis was analyzed. Results The levels of serum miR-124 and miR-210 expression in the stenosis group were lower compared to in the non-stenosis group. Addition-ally,the levels of hs-CRP and Hcy were higher in the stenosis group compared to the non-stenosis group(P<0.05). Furthermore,the levels of serum miR-124 and miR-210 expression were lower in the severe stenosis group compared to the mild and moderate stenosis groups(P<0.05). The highest levels of hs-CRP and Hcy were observed in the highest in severe stenosis group,followed by the moderate stenosis group and the mild stenosis group(P<0.05). Lastly,the levels of serum miR-124 and miR-210 expression were found to be negatively correlated with hs-CRP ,Hcy levels and the severity of carotid stenosis (P<0.05). Conclusion The miR-124 and miR-210 may be involved in the development of carotid stenosis. These miRNAs can serve as additional indicators to assess the severity of carotid stenosis in non-cardiogenic cerebral infarction.
万方数据
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