Predictive value of serum SOST,ALP and TyG index on coronary artery calcification in maintenance hemodialysis patients
Objective To investigate the predictive value of serum levels of osteosclerosis protein (SOST),alkaline phosphatase(ALP)and triglyceride glucose(TyG)on coronary artery calcification in maintenance hemodialysis patients. Methods A total of 110 maintenance hemodialysis patients admitted to our hospital from December 2021 to February 2023 were selected as the study subjects. They were divided into two groups:one group without calcification(n=43)and and one group with calcification(n=67),based on their coronary artery calcification scores. The differences in serum SOST ,ALP and TyG index between the two groups were compared to analyze the independent factors that influence patients with coronary artery calcification as well as the predictive value and correlation of coronary artery calcification. Results The levels of SOST,ALP and TyG index in the calcification group were higher than those in the non-calcification group(t=7.438,4.012,4.279,P<0.05). Spearman analysis showed a positive correlation between serum SOST,ALP and TyG index and coronary artery calcification in maintenance hemodialysis patients (r=0.584,0.356, 0.351,P<0.001). Logistic analysis revealed that serum SOST and ALP levels,TyG index,age and diabetes mellitus were independent risk factors for poor coronary artery calcification in maintenance hemodialysis patients(P<0.05). The ROC curve demnostrated that the combination of serum SOST ,ALP and TyG index was more effective in predicting coronary artery calcification in maintenance hemodialysis patients ,with an area under the curve(AUC)of 0.922. Conclusion Serum levels of SOST,ALP and TyG index are closely associated with coronary artery calcification in patients undergoing maintenance hemodialysis. Furthermore ,their expression demonstrates a reliable predictive value for coronary artery calcification in thses patients.