首页|血清SOST、ALP水平及TyG指数对维持性血液透析患者冠状动脉钙化的预测价值

血清SOST、ALP水平及TyG指数对维持性血液透析患者冠状动脉钙化的预测价值

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目的 探讨血清骨硬化蛋白(SOST)、碱性磷酸酶(ALP)水平及三酰甘油葡萄糖(TyG)指数对维持性血液透析患者冠状动脉钙化的预测价值.方法 选取2021年12月至2023年2月于合肥市妇幼保健院就诊的110例维持性血液透析患者作为研究对象,按照患者冠状动脉钙化积分将患者分为无钙化组(n=43)和钙化组(n=67).对比两组的血清SOST、ALP水平及TyG指数差异,分析患者冠状动脉钙化的独立影响因素及对冠状动脉钙化的预测价值及相关性.结果 钙化组的SOST、ALP水平、TyG指数高于无钙化组(t=7.438、4.012、4.279,P<0.05).Spearman分析显示,血清SOST、ALP水平及TyG指数与维持性血液透析患者冠状动脉钙化发生呈正相关(r=0.584、0.356、0.351,P<0.001).Logistic分析显示,血清SOST、ALP水平及TyG指数、年龄、糖尿病是维持性血液透析患者冠状动脉钙化不良的独立危险因素(P<0.05).ROC曲线显示,血清SOST、ALP水平及TyG指数联合预测维持性血液透析患者冠状动脉钙化的效能更高,其曲线下面积(AUC)为0.922.结论 血清SOST、ALP水平及TyG指数与维持性血液透析患者冠状动脉钙化密切相关,其表达对维持性血液透析患者冠状动脉钙化具有良好的预测价值.
Predictive value of serum SOST,ALP and TyG index on coronary artery calcification in maintenance hemodialysis patients
Objective To investigate the predictive value of serum levels of osteosclerosis protein (SOST),alkaline phosphatase(ALP)and triglyceride glucose(TyG)on coronary artery calcification in maintenance hemodialysis patients. Methods A total of 110 maintenance hemodialysis patients admitted to our hospital from December 2021 to February 2023 were selected as the study subjects. They were divided into two groups:one group without calcification(n=43)and and one group with calcification(n=67),based on their coronary artery calcification scores. The differences in serum SOST ,ALP and TyG index between the two groups were compared to analyze the independent factors that influence patients with coronary artery calcification as well as the predictive value and correlation of coronary artery calcification. Results The levels of SOST,ALP and TyG index in the calcification group were higher than those in the non-calcification group(t=7.438,4.012,4.279,P<0.05). Spearman analysis showed a positive correlation between serum SOST,ALP and TyG index and coronary artery calcification in maintenance hemodialysis patients (r=0.584,0.356, 0.351,P<0.001). Logistic analysis revealed that serum SOST and ALP levels,TyG index,age and diabetes mellitus were independent risk factors for poor coronary artery calcification in maintenance hemodialysis patients(P<0.05). The ROC curve demnostrated that the combination of serum SOST ,ALP and TyG index was more effective in predicting coronary artery calcification in maintenance hemodialysis patients ,with an area under the curve(AUC)of 0.922. Conclusion Serum levels of SOST,ALP and TyG index are closely associated with coronary artery calcification in patients undergoing maintenance hemodialysis. Furthermore ,their expression demonstrates a reliable predictive value for coronary artery calcification in thses patients.

SOSTALPTyGMaintenance hemodialysisCoronary artery calcification

崔丽、史光彩、苏超、王刚、石保艳

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合肥市妇幼保健院肾内科,安徽,合肥230011

血清骨硬化蛋白 碱性磷酸酶 三酰甘油葡萄糖指数 维持性血液透析 冠状动脉钙化

安微省妇幼保健院院级科研项目

zd2022-1-3

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(2)
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