Application of sFlt - 1, PLGF and PAPP - A in clinical diagnosis and prognosis of preeclampsia
Objective To explore the application effect of soluble FMS - like tyrosine kinase 1 (sFlt-1),placental growth factor(PLGF)and pregnancy associated plasma protein-A(PAPP-A)in the clinical diagnosis and prognosis of preeclampsia. Methods A total of 151 pregnant women with preeclampsia admitted to Beijing Daxing District People's Hospital from June 2021 to January 2023 were selected as the observation group,and 149 pregnant women who underwent pregnancy examination and had normal results during the same period were selected as the control group. The levels of sFlt-1,PLGF and PAPP-A were compared between the two groups;according to the severity of pre eclampsia,pregnant women were divided into the mild pre eclampsia group and the severe pre eclampsia group,and the levels of sFlt-1,PLGF and PAPP-A of pregnant women with different severity of preeclampsia were compared. The general data of different pregnancy outcomes,the changes of serum sFlt-1,PLGF and PAPP-A were compared in the observation group. Multivariate binary logistic regression equation was included to analyze the risk factors that affects the prognosis of preeclampsia. Results Serum PLGF and PAPP-A levels in the observation group were lower than those in the control group,and sFlt-1 levels were higher than those in the control group,with statistical significance(P<0.05). There were 95 cases in the mild pre eclampsia group and 56 cases in the severe eclampsia group,the PLGF and PAPP-A levels in the severe pre eclampsia group were lower than those in the mild pre eclampsia group,and sFlt-1 levels in the severe pre eclampsia group were higher than those in the mild pre eclampsia group,with statistical significance(P<0.05). There were 117 cases in the normal pregnancy group and 34 cases in the adverse pregnancy group,and there were statistically significant differences in the history of diabetes,hypertension,sFlt-1,PLGF and PAPP-A between the two groups(P<0.05),while there were no statistically significant differences in age,BMI and gestational age between the two groups(P>0.05). Logistic results showed that the history of diabetes,history of hypertension,increase of sFlt-1 level,decrease of PAPP-A level and decrease of PLGF level were risk factors affecting the prognosis of preeclampsia patients (P<0.05). Conclusion The expression of sFlt-1,PLGF and PAPP-A in the serum of pregnant women with preeclampsia is abnormal. These three markers can be used for the early diagnosis of preeclampsia.
万方数据
维普
