Relationship between serum YKL-40,IL-33,copeptin levels and prognosis of patients with acute myocardial infarction
Objective To investigate the relationship between the levels of serum chitinase protein(YKL-40),interleukin-33(IL-33),and copeptin and the prognosis of patients with acute myocardial infarction(AMI). Methods A total of 200 patients with acute myocardial infarction admitted to the Intensive Care Unit (CCU) of the Cardiology Department at the First Hospital of Qinhuangdao City from September 2020 to March 2021 were selected as the study subjects. They were divided into two groups based on their prognosis:a good prognosis group and a poor prognosis group,depending on whether they experienced cardiovascular adverse events. The serum levels of YKL-40,IL-33 and copeptin between the two groups was measured and compared. Spearman correlation analysis was used to analyze the relationship between serum YKL-40,IL-33 and copeptin levels and the prognosis of patients with acute myocardial infarction. Multivariate logistic regression was used to analyze the independent influencing factors of poor prognosis in patients with acute myocardial infarction,and the receiver operating characteristic curve(ROC)was drawn to evaluate the predictive value of serum YKL-40,IL-33 and copeptin levels for poor prognosis in patients with acute myocardial infarction. Results The serum levels of YKL-40,IL-33 and copeptin in the group with a good prognosis were lower than those in the group with a poor prognosis group,and the differences were statistically significant(t=7.788,5.415,4.534,P<0.05). Spearman correlation analysis showed a positive correlation between serum YKL-40,IL-33 and copeptin levels and poor prognosis in patients with myocardial infarction(r=0.450,0.340,0.274,P<0.001). Logistic multivariate regression analysis revealed that age, hypertension,YKL-40,IL-33 and copeptin overexpression were independent risk factors for poor prognosis in patients with acute myocardial infarction(P<0.05). The ROC curve demonstrated that the combined effect of serum YKL-40,IL-33 and copeptin was more effective in predicting the adverse prognosis of acute myocardial infarction. The area under the curve (AUC) for serum YKL-40,IL-33 and copeptin was 0.872 with a sensitivity of 79.0％and specificity of 81.9％. Conclusion Serum levels of YKL-40,IL-33 and copeptin are closely associated with the poor prognosis of patients with acute myocardial infarction. Their expressions have a significant predictive value for the prognosis of acute myocardial infarction.
万方数据
维普
