The significance of detecting peripheral blood T lymphocytes,IL-4 and chemokine CXCL13 in patients with neurosyphilis
Objective To analyze the clinical significance of peripheral blood T lymphocyte ,in-terleukin-4(IL-4)and chemokine CXC ligand 13(CXCL13)levels in patients with neurosyphilis. Methods One hundred and eighty-eight patients with syphilis were admitted to West China Hospital of Sichuan University from September 2020 to January 2023. The study included 62 patients who were serofixed(serofixed group) and 126 patients with neurosyphilis(neurosyphilis group),which consisted of 31 cases of asymptomatic type, 58 cases of early stage and 37 cases of late stage. Additionally,80 normal healthy individuals(control group) who received outpatient and physical examinations at our hospital during the same period were selected. The levels of peripheral blood T lymphocytes,IL-4 and chemical factor CXCL13 were compared among different groups of people and patients with different degrees of syphilis. The Receiver operating characteristic (ROC);curve was used to analyze the diagnostic value of the combined detection of peripheral blood T lymphocytes , IL-4 and chemokine CXCL13 in the identification of early neurosyphilis. Results CD4+and CD4+/CD8+values:neurosyphilis group<serofixation group<control group,the difference was statistically significant(P<0.05). IL-4 and CXCL13 levels:neurosyphilis group>serum-fixed group>control group,the difference was statistically significant(P<0.05). CD4+ and CD4+/CD8+ values:late group <early group <asymptomatic group,the difference was statistically significant(P<0.05). IL-4 and CXCL13 levels:late group>early group>asymptomatic group,the difference was statistically significant(P<0.05). The ROC analysis showed that the combined detection of peripheral blood T lymphocytes,IL-4 and CXCL13 had a sensitivity and specificity of 89.68％, 91.11％,with an AUC of 0.862(95％ CI:0.806-0.933). This was higher than the single examination of peripheral blood T lymphocytes,IL-4 and chemokine CXCL13,as well as higher than the three-indicator single test(P<0.05). Conclusion The changes in T lymphocytes,IL-4 and CXCL13 levels in peripheral blood are closely related to the progression of neurosyphilis in patients. The combined detection of these three factors has better sensitivity and specificity for early identification and diagnosis of neurosyphilis. It has greater application value in assessing the prognosis of neurosyphilis and providingclinical guidance.
Peripheral blood T lymphocytesIL-4Chemokine CXCL13Neurosyphilis
万方数据
维普
