Effect of mycophenolate mortiate combined with prednisone on urinary β2-MG,U-mAlb and α1-MG levels in patients with IgA nephropathy
Objective To observe the effects of mortemycophenate combined with prednisone on urinary β2-microglobulin(β2-MG),urinary microalbumin(U-mAlb)and urinary α1-microglobulin(α1-MG)levels in patients with IgA nephropathy. Methods Eighty-nine patients with IgA nephropathy were admitted to the Department of Nephrology at the First Hospital of Qinhuangdao City from January 2019 to January 2022. They were selected as the study participants,and divided into two groups using the envelope random method:the prednisone group(n=43)and the combination group(n=46). The prednisone group received conventional treatment along with low-dose prednisone,while the combination group received mycophenolate in addition to prednisone. The levels of urinary β2-MG,U-mAlb,α1-MG,n-acetyl-β-D glucosaminidase (NAG) and urinary podocytoprotein were compared between the two groups. The differences in renal function,vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),transforming growth factor-α(TGF-α),blood uric acid and hemoglobin between the two groups were also measured. The therapeutic effects of the two groups were analyzed. Results After treatment ,the levels of urine β2-MG , U-mAlb,α1-MG,NAG,urinary nephropathy protein(NPHS1)protein,Podocin protein,VEGF,TGF-β1, TGF-α,renal function decreased in both groups. The levels of serum creatinine(Scr)and urea nitrogen(BUN) in the combination group were lower than those in the prednisone group(P<0.05). The total effective rate of the combined group was higher than that of prednisone group,and the difference was statistically significant(P<0.05). Conclusion The combination of mortemycophenol ester and low-dose prednisone in the treatment of IgA nephropathy can protect renal cells,reduce kidney injury and enhance the effectiveness of treatment.
万方数据
维普
