Study on the value of peripheral blood CTC,PD-L1 and S100A6BP in diagnosis and prognosis of patients with gastric cancer
Objective To investigate the diagnostic and prognostic value of peripheral blood circulating tumor cells (CTC),programmed death factor ligand-1 (PD-L1),and calcyclin binding protein (S100A6BP)levels in patients with gastric cancer. Methods A total of 182 patients with gastric cancer were admitted to Nanyang First People's Hospital from May 2020 to May 2022 and were selected as the observation group. Based on their prognosis,they were divided into two groups:the good prognosis group(124 cases) and the poor prognosis group(58 cases). Additionally,90 healthy volunteers were chosen as the control group during the same period. The levels of CTC,PD-L1 and S100A6BP in the peripheral blood of all subjects were compared,and the diagnosis and prognosis value of CTC,PD-L1 and S100A6BP alone and combination were evaluated for patients with gastric cancer patients. Results The levels of CTC,PD-L1 and S100A6BP in the peripheral blood of the observation group were higher than those of the control group ,with statistical significance(P<0.05). The sensitivity and specificity of CTC,PD-L1 and S100A6BP in diagnosing gastric cancer was higher than that of single detection(P<0.05). In the good prognosis group,the tumor diameter,CTC, PD-L1,S100A6BP,TNM(Ⅲ～Ⅳ),middle and high differentiation,lymph node metastasis,and depth of invasion(T3-T4)were all significantly lower than those in the poor prognosis group(P<0.05). Conversely,the levels of TNM(Ⅰ～Ⅱ),low differentiation and depth of invasion(T1-T2)were significantly higher in the good prognosis group,compared to the poor prognosis group(P<0.05). Multivariate logistic regression analysis showed that tumor diameter,TNM stage,degree of differentiation,depth of invasion,lymph node metastasis,CTC,PD-L1 and S100A6BP were independent risk factors for poor prognosis of gastric cancer(P<0.05). The ROC curve analysis demonstrated that the prognostic AUC of CTC ,PD-L1 and S100A6BP single and combined detection was 0.808,0.845,0.874 and 0.955,respectively(P<0.05). Conclusion CTC,PD-L1 and S100A6BP are highly expressed in the peripheral blood of patients with gastric cancer. This expression is closely related to the pathological characteristics and prognosis of these patients. The combined detection of CTC,PD-L1 and S100A6BP has a high predictive value for diagnosing and determining the prognosis of patients with gastric cancer.
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