Effects of laparoscopic focus resection combined with GnRH-a on reproductive hormone levels and Th1/Th2 cell balance in patients with endometriosis
Objective To explore the effects of laparoscopic resection combined with gonadotropin-releasing hormone agonist (GnRH-a) on reproductive hormone levels and the ratio of helper T cell 1 (Th1)to helper T cell 2(Th2)cell balance in patients with endometriosis. Methods A total of 148 patients with endometriosis from the gynecology department of Nanyang Central Hospital from August 2020 to August 2022 were selected as study subjects. They were divided into two groups:an observation group and a control group based on the treatment plan,with 74 cases in each group. Both groups underwent endoscopic focal resection. The observation group received treatment with GnRH-a ,while the control group was treated with mife-pristone tablets for 6 months. The clinical efficacy,reproductive hormone levels,Th1/Th2 cell balance and adverse reactions were compared between the two groups. Results The clinical effect of the observation group was 93.24% higher than that of the control group(78.38%). The difference was statistically significant(x2=6.715,P<0.05). After treatment,the levels of serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)decreased in both groups. The observation group had lower levels than the control group,and the difference was statistically significant(t=7.941,7.858,13.353;P<0.05). The levels of serum interferon gamma(IFN-γ),IFN-γ/interleukin-4(IL-4),interleukin-2(IL-2)and IL-2/interleukin-10 (IL-10)increased in both groups after treatment. The levels of IFN-γ,IFN-γ/IL-4,IL-2,IL-2/IL-10 in the observation group were higher than those in the control group,and the differences were statistically significant (t=14.283,14.283,11.745,45.061,P<0.05). The levels of IL-4 and IL-10 in the observation group were lower than those in the control group,and the difference was statistically significant(t=12.495,15.085,P<0.05). Conclusion Laparoscopic focal resection combined with GnRH-a in the treatment of endometriosis patients can improve clinical efficacy,reproductive hormone levels and immune function.