首页|腹腔镜下病灶切除术联合GnRH-a对子宫内膜异位症患者生殖激素水平及Th1/Th2细胞平衡的影响

腹腔镜下病灶切除术联合GnRH-a对子宫内膜异位症患者生殖激素水平及Th1/Th2细胞平衡的影响

扫码查看
目的 探究腹腔镜下病灶切除术联合促性腺激素释放激素激动剂(GnRH-a)对子宫内膜异位症患者生殖激素水平及辅助性T细胞1(Th1)与辅助性T细胞2(Th2)的比值(Th1/Th2)细胞平衡的影响.方法 选取2020年8月至2022年8月南阳市中心医院妇科的子宫内膜异位症患者148例,根据治疗方案分为观察组和对照组,各74例.两组均采用腔镜下病灶切除术,观察组联合GnRH-a治疗,对照组采用米非司酮片治疗,治疗6个月,比较两组患者的临床疗效、生殖激素水平、Th1/Th2细胞平衡及不良反应.结果 观察组的临床疗效为93.24%高于对照组临床疗效78.38%,差异有统计学意义(x2=6.715,P<0.05).两组患者用药后血清卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平较术前均降低,且观察组低于对照组,差异有统计学意义(t=7.941,7.858,13.353,P<0.05).两组患者用药后的血清γ干扰素(IFN-γ)、IFN-γ/白细胞介素-4(IL-4)及白细胞介素-2(IL-2)、IL-2/白细胞介素-10(IL-10)水平较术前均升高,且观察组IFN-γ、IFN-γ/IL-4及IL-2、IL-2/IL-10水平均比对照组高,差异有统计学意义(t=14.283,14.283,11.745,45.061,P<0.05);IL-4、IL-10水平较术前均降低,且观察组IL-4、IL-10水平比对照组低,差异有统计学意义(t=12.495,15.085,P<0.05).结论 腹腔镜下病灶切除术联合GnRH-a治疗子宫内膜异位症患者,可提高临床疗效,改善患者生殖激素水平和免疫功能.
Effects of laparoscopic focus resection combined with GnRH-a on reproductive hormone levels and Th1/Th2 cell balance in patients with endometriosis
Objective To explore the effects of laparoscopic resection combined with gonadotropin-releasing hormone agonist (GnRH-a) on reproductive hormone levels and the ratio of helper T cell 1 (Th1)to helper T cell 2(Th2)cell balance in patients with endometriosis. Methods A total of 148 patients with endometriosis from the gynecology department of Nanyang Central Hospital from August 2020 to August 2022 were selected as study subjects. They were divided into two groups:an observation group and a control group based on the treatment plan,with 74 cases in each group. Both groups underwent endoscopic focal resection. The observation group received treatment with GnRH-a ,while the control group was treated with mife-pristone tablets for 6 months. The clinical efficacy,reproductive hormone levels,Th1/Th2 cell balance and adverse reactions were compared between the two groups. Results The clinical effect of the observation group was 93.24% higher than that of the control group(78.38%). The difference was statistically significant(x2=6.715,P<0.05). After treatment,the levels of serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)decreased in both groups. The observation group had lower levels than the control group,and the difference was statistically significant(t=7.941,7.858,13.353;P<0.05). The levels of serum interferon gamma(IFN-γ),IFN-γ/interleukin-4(IL-4),interleukin-2(IL-2)and IL-2/interleukin-10 (IL-10)increased in both groups after treatment. The levels of IFN-γ,IFN-γ/IL-4,IL-2,IL-2/IL-10 in the observation group were higher than those in the control group,and the differences were statistically significant (t=14.283,14.283,11.745,45.061,P<0.05). The levels of IL-4 and IL-10 in the observation group were lower than those in the control group,and the difference was statistically significant(t=12.495,15.085,P<0.05). Conclusion Laparoscopic focal resection combined with GnRH-a in the treatment of endometriosis patients can improve clinical efficacy,reproductive hormone levels and immune function.

Laparoscopic focal resectionEMsGnRH-a

叶永生、徐燕、王远航、徐小晶、孙君华、倪鸣

展开 >

河南省南阳市中心医院妇三科,河南,南阳473000

腹腔镜下病灶切除术 子宫内膜异位症 促性腺激素释放激素激动剂

河南省科技厅重点项目

20210506

2024

分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
年,卷(期):2024.16(2)
  • 15