Correlation between serum TLR4 and PTEN and clinicopathologic characteristics and prognosis in patients with idiopathic membranous nephropathy
Objective To explore the correlation between serum Toll-like receptor 4 (TLR4), phosphatase and tensin homologue-deleted chromosome ten gene(PTEN)and the clinicopathologic characteristics and prognosis of patients with idiopathic membranous nephropathy(IMN). Methods A total of 224 IMN patients were treated at Hebei Yiling Hospital from January 2019 to January 2022. These patients were divided into two groups based on their prognosis:174 patients in the good prognosis group and 50 patients in the poor prognosis group. Additinoally,100 healthy individuals from our hospital were included as the control group. The levels of serum TLR4 and PTEN in the subjects were measuredusing enzyme-linked immunosorbent assay (ELISA). Pearson correlation aanalysis was used to examine the relationship between serum TLR4 levels and PTEN levels in IMN patients. Multivariate logistic regression was employed to identify the factors influencing poor prognosis in IMN patients. Furthermore,the potential of serum TLR4 and PTEN as prognosis markers for IMN patients was evaluated using receiver operating characteristic(ROC)curve analysis. Results The levels of serum TLR4 and PTEN in the IMN group were higher than those in the control group,and the differences were statistically significant(t=12.918,13.249,P<0.05). Simarly,the serum levels of TLR4 and PTEN in the poor prognosis group were significantly higher than those in the good prognosis group ,and the differences were statistically significant (t=11.608,12.965,P<0.05). There was a positive correlation between serum TLR4 and PTEN levels in IMN patients. High levels of TLR4,PTEN,IgG and hypertension were identified as independent risk factors for poor prognosis in IMN patients(P<0.05). The area under the curve(AUC)for serum TLR4 and PTEN levels in predicting poor prognosis in IMN patients were 0.878 and 0.868,respectively. When combined,the AUC increased to 0.941,which was significantly higher than the AUC predicted by the two alone(z=1.874 and 2.065,P<0.05). The specificity was 0.89,and the sensitivity was 0.88. Conclusion Serum levels of TLR4 and PTEN are closely associated with the staging of patients with IMN,as well as with glomerulosclerosis. These factors also have a certain predictive value for the prognosis of IMN.
TLR4Phosphatase and tensin homologue-deleted chromosome ten geneIMN
万方数据
维普
