Objective To investigate the changes of renin(REN),angiotensin(AngⅡ)and brain natriuretic peptide(BNP)in patients with chronic heart failure(CHF)and its relationship with cardiac function. Methods The clinical data of 84 patients with CHF admitted to Jinzhai County People's Hospital from February 2019 to February 2023 were selected(CHF group),another 66 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy control group. We analyzed the levels of REN,Ang Ⅱ and BNP in the two groups;and the levels of REN,Ang Ⅱ,BNP and cardiac function of patients with different cardiac function grades were analyzed by variance;the correlations of REN,AngⅡand BNP with cardiac function indexes were analyzed by pearson correlation analysis;and ROC curve was used to evaluate the predictive value of REN,AngⅡand BNP levels for CHF. Results The levels of REN, Ang Ⅱ and BNP in CHF group were significantly higher than those in control group ,and the difference was statistically significant(P<0.05). Comparison of the levels of REN,Ang Ⅱand BNP in CHF patients with different cardiac function grades:NYHA Ⅱgroup<NYHA Ⅲ group<NYHA Ⅳ group,and the difference was statistically significant(P<0.05). Comparison of left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter (LVESD) in CHF patients with different cardiac function grades:NYHAⅡ group<NYHA Ⅲ group<NYHA Ⅳ group;Comparison of left ventricular ejection fraction(LVEF):NYHA Ⅱ group>NYHAⅢgroup>NYHA Ⅳ group,and the difference was statistically significant(P<0.05). The correlation analysis showed that REN,AngⅡ and BNP were positively correlated with LVEDD and LVESD,but were negatively correlated with LVEF,and REN,Ang Ⅱ and BNP were positively correlated with cardiac function grading(P<0.05). ROC results showed that the AUC of REN Ang Ⅱ and BNP. The AUC of REN+Ang Ⅱ +BNP was 0.901,which was significantly higher than that of single diagnosis(P<0.05). Conclusion The levels of REN,Ang Ⅱand BNP in CHF patients were abnormally increased,and the three indexes were significantly correlated with cardiac function grading ,these factors are expected to become reliable indicators for clinical diagnosis of CHF and evaluation of cardiac function classification.
维普
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