Correlation between blood uric acid,urinary protein creatinine ratio,urinary microalbumin level and diabetic nephropathy in elderly patients with type 2 diabetes mellitus
Objective To investigate the correlation between serum uric acid ,urinary protein creatinine ratio(UACR)and urinary microalbumin(UmAlb)levels and diabetic nephropathy(DKD)in elderly patients with type 2 diabetes mellitus. Methods A total of 140 elderly patients with type 2 diabetes admitted to the Endocrinology Department of Linquan County People ' s Hospital from January 2020 to January 2023 were selected as the observation group. 80 healthy volunteers who underwent routine physical examinations during the same period were chosen as the control group. The observation group was further divided into subgroups based on the patients ' glomerular filtration rate (eGFR):42 cases of non-diabetic nephropathy (NDKD),39 cases of early DKD,34 cases of middle DKD and 25 cases of late DKD. In addition,60 healthy volunteers were selected as an additional control group. The levels of uric acid ,UACR and UmAlb in the blood of all subjects were compared,and the correlation between theselevels and the stage of DKD,as well as the diagnostic efficacy of DKD were analyzed. Results The levels of uric acid,UACR and UmAlb in the observation group were higher than those in the control group(t=4.641,25.656,38.833,P<0.05). The levels of uric acid,UACR and UmAlb in the blood were higher in late DKD,followed by middle DKD,and early DKD(F=4.887,538.570,684.184,P<0.05). Spearman analysis showed a positive correlation between blood uric acid,UACR,UmAlb levels,and DKD stage (P<0.001). Fasting blood glucose,mean arterial pressure(MAP),triglyceride(TG),blood uric acid,UACR and UmAlb were all higher in DKD patients compared to NDKD patients,the durstion of the disease was longer in DKD patients. The difference was statistically significant(t=3.866,14.824,7.718,5.022,33.588,53.438,9.364,P<0.05). Logistic multivariate regression analysis showed that fasting blood glucose,MAP,TG,blood uric acid,UACR and UmAlb were independent influencing factors for DKD in T2DM patients(P<0.05). The AUC of serum uric acid and the combined detection was superior to the single detection(P<0.05). Conclusion Serum uric acid,UACR and UmAlb levels are positively correlated with the stage of DKD. The combined detection of these three factors has high diagnostic efficacy for DKD.
万方数据
维普
