Diagnostic value of joint detection of NLR,PCT,IL-6,CRP and SAA in bloodstream infections caused by different pathogenic bacteria
Objective To investigate the diagnostic value of joint detection of neutrophil-to-lymphocyte ratio(NLR),procalcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP)and serum amyloid A(SAA)in bloodstream infections(BSI)caused by different pathogenic bacteria. Methods A total of 200 patients with BSI who were treated at Dongguan Qingxi Hospital from May 2021 to May 2023 were select-ed as the study subjects. The patients were divide patients into three groups based on the results of pathogen detection:Gram positive,Gram negative,and fungal groups. The levels of NLR,PCT,IL-6,CRP and SAA were measured in each group. The diagnostic value of each indicator and the combination of these indicators in BSI caused by different pathogenic bacteria was analyzed using the receiver operating characteristic (ROC) curve. Results Among the 200 patients,92 were infected with Gram-positive bacteria,101 were infected with Gram-negative bacteria and 7 were infected with fungi. There were statistically significant differences in the levels of PCT,IL-6,CRP and SAA(P<0.05). The results of ROC curve analysis showed that the area under the curve(AUC)values of SAA were the largest(0.997,0.927 and 0.991). There was no statistically significant difference in AUC compared to single diagnosis with SAA (P>0.05). Conclusion The levels of PCT,IL-6,CRP and SAA vary in patients with BSI caused by different pathogenic bacteria. These levels can be utilized to differentiate between BSI caued by different pathogenic bacteria. Among these markers ,SAA demonstrates the highest diagnostic efficacy.
Bloodstream infectionPathogenic bacteriaNeutrophil-to-lymphocyte ratioProcalcitoninInterleukin-6C-reactive protein
万方数据
维普
