The predictive value of serum FGF21,Sfrp5 and miRNA-21 for in-stent restenosis after percutaneous coronary intervention in patients with coronary heart disease
Objective To investigate the predictive value of serum fibroblast growth factor 21 (FGF21),secreted frizzled protein 5(Sfrp5)and microRNA-21(miRNA-21)for in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD). Methods A total of 218 CHD patients who underwent PCI at Shangshui County People's Hospital from January 2021 to September 2022 were selected as the CHD group,and 97 hospitalized patients without cardiovascular disease during the same period were selected as the control group. The levels of FGF21,Sfrp5 and miRNA-21 were compared between the two groups. The CHD group was followed up for 6 months after operation,and was divided into the ISR group(n=56)and the non-ISR group(n=162)based on whether ISR occurred or not. The aim was to analyze the influencing factors of ISR after PCI in CHD patients,and to determine the predictive value of FGF21,Sfrp5 and miRNA-21 for ISR. Results FGF21 and miRNA-21 levels were higher in the CHD group compared to the control group,while the level of Sfrp5 was lower than that in the control group(t=11.196, 15.030,13.685,P<0.05). Low density lipoprotein cholesterol(LDL-C),FGF21 and miRNA-21 in the ISR group were higher than those in the non-ISR group,and the level of Sfrp5 was lower than that in the non-ISR group,the differences were statistically significant(t=7.093,7.216,6.388,P<0.05). The rates of smoking and diabetes mellitus in the ISR group were higher than those in the non-ISR group,the differences were statistically significant(x2=6.015,11.295,P<0.05). Multivariate logistic regression analysis showed that LDL-C,diabetes mellitus,FGF21,Sfrp5 and miRNA-21 were the influencing factors for ISR after PCI in CHD patients(P<0.05). The ROC curve analysis showed that the AUC for FGF21,Sfrp5 and miRNA-21 alone and combined detection in predicting ISR after PCI were 0.772,0.758,0.763 and 0.905,respectively. Conclusion Serum FGF21,Sfrp5 and miRNA-21 are abnormally expressed in CHD patients with ISR after PCI. The combined detection of the three levels has a high application value in predicting ISR after PCI in CHD patients.
万方数据
维普
