The diagnostic value of osteolytic bone metabolism markersⅠCTP,miR-107 and TRACP-5b detection in lung cancer bone metastasis
Objective To analyze the diagnostic value of serum type Ⅰ collagen cross-linked car-boxyl terminal peptide(ⅠCTP),miR-107 and tartrate-resistant acid phosphatase 5b(TRACP-5b)detection in bone metastasis of lung cancer. Methods A total of 122 patients with advanced lung cancer treated at Henan Provincial People's Hospital from October 2020 to December 2022 were divided into two groups:the bone metastasis group(58 cases)and the non-bone metastasis group(64 cases)based on the presence of bone metastasis. The study consisted of four parts:Comparison of CTP,miR-107,and TRACP-5b levels between the bone metastasis group and the non-bone metastasis group. Comparison of CTP,miR-107,and TRACP-5b levels within the bone metastasis group. Comparison of the number of different bone metastasis group and the levels of CTP,miR-107,and TRACP-5b were compared. Analysis of the diagnostic value of CTP,miR-107,and TRACP-5b in bone metastasis of lung cancer. Results The levels of CTP,miR-107,and TRACP-5b in the bone metastasis groupⅠwere higher than those in the non-bone metastasis group,and the differences were statistically significant(P<0.05). The levels ofⅠCTP,miR-107,and TRACP-5b:were higher in stages Ⅲ-Ⅳ compared to stages Ⅰ-Ⅱ and 0,and the difference was statistically significant(P<0.05). The levels of CTP, miR-107,and TRACP-5b were higher in the ≥ 3 metastasis groups compared to the ≤ 2 metastasis groups, and the difference was statistically significant(P<0.05). The sensitivity,specificity,and accuracy of ICTP, miR-107,and TRACP-5b in diagnosing bone metastasis of lung cancer were 96.42％,93.93％ and 95.08％ respectively,which were higher than those of the individual indercator,and the difference was statistically significant(P<0.05). Conclusion The levels of CTP,miR-107,and TRACP-5b are closely associated with the occurrence of lung cancer bone metastasis. TRACP-5b has the highest sensitivity,specificity,and accuracy in detecting lung cancer bone metastasis. The combined detection of the three can effectively improve the diagnos-tic value of lung cancer bone metastasis. collagen cross-linked car-boxyl terminal peptide(ⅠCTP),miR-107 and tartrate-resistant acid phosphatase 5b(TRACP-5b)detection in bone metastasis of lung cancer. Methods A total of 122 patients with advanced lung cancer treated at Henan Provincial People's Hospital from October 2020 to December 2022 were divided into two groups:the bone me-tastasis group(58 cases)and the non-bone metastasis group(64 cases)based on the presence of bone metasta-sis. The study consisted of four parts:Comparison of CTP,miR-107,and TRACP-5b levels between the bone metastasis group and the non-bone metastasis group. Comparison of CTP,miR-107,and TRACP-5b levels within the bone metastasis group. Comparison of the number of different bone metastasis group and the levels of CTP,miR-107,and TRACP-5b were compared. Analysis of the diagnostic value of CTP,miR-107,and TRACP-5b in bone metastasis of lung cancer. Results The levels of CTP,miR-107,and TRACP-5b in the bone metastasis groupⅠwere higher than those in the non-bone metastasis group,and the differences were statistically significant(P<0.05). The levels of ⅠCTP,miR-107,and TRACP-5b:were higher in stages Ⅲ-Ⅳ compared to stages Ⅰ-Ⅱ and 0,and the difference was statistically significant(P<0.05). The levels of CTP, miR-107,and TRACP-5b were higher in the ≥ 3 metastasis groups compared to the ≤ 2 metastasis groups, and the difference was statistically significant(P<0.05). The sensitivity,specificity,and accuracy of ICTP, miR-107,and TRACP-5b in diagnosing bone metastasis of lung cancer were 96.42％,93.93％and 95.08％ respectively,which were higher than those of the individual indercator,and the difference was statistically significant(P<0.05). Conclusion The levels of CTP,miR-107,and TRACP-5b are closely associated with the occurrence of lung cancer bone metastasis. TRACP-5b has the highest sensitivity,specificity,and accuracy in detecting lung cancer bone metastasis. The combined detection of the three can effectively improve the diagnostic value of lung cancer bone metastasis.
万方数据
维普
