Diagnostic value of serum HE4,ROMA value combined with CA724 detection in CA125-negative ovarian cancer
Objective To analyze the diagnostic value of serum human epididymal protein 4 (HE4),ovarian malignant tumor risk prediction model(ROMA)value combined with carbohydrate antigen CA724(CA724)detection in carbohydrate antigen 125(CA125)-negative ovarian cancer. Methods A total of 159 patients with ovarian cancer who were treated at Linyi Cancer Hospital from January 2022 to June 2022 were selected as the study subjects. All patients were tested using serum CA125. The criteria for determining negative and positive results were as follows:CA125>35 U/mL was considered positive,while CA125≤ 35 U/mL was considered negative. The study included 84 cases of CA125-negative ovarian cancer and 75 cases of CA125-positive ovarian cancer. The levels of serum CA724,HE4 and ROMA index were compared between the two groups. The diagnostic efficacy of serum CA724,HE4 and ROMA index individually and combined, in detecting the CA125-negative ovarian cancer group was analyzed. Additionally,the levels of serum CA724, HE4 and ROMA index in different stages of the CA125-negative ovarian cancer group were compared. The correlation between serum CA724,HE4 levels and ROMA index was analyzed. Results The serum levels of CA724,HE4 and ROMA index in the CA125-positive group were lower than those in the CA125-negative group,and the difference was statistically significant(P<0.05). The sensitivity,specificity and accuracy of the combined diagnosis of CA724,HE4 and ROMA index in patients with CA125-negative ovarian cancer were 92.73％,89.66％ and 91.67％,respectively,which were higher than those of the three tests alone(P<0.05). The levels of serum CA724,HE4 and ROMA index in stage Ⅲ-Ⅳ patients of the CA125-negative ovarian cancer group were significantly higher than those in stage Ⅰ-Ⅱ patients,and the difference was statistically significant(P<0.05). Pearson correlation analysis showed that,the serum CA724 and HE4 levels were positively correlated (r=0.932,P<0.001). Serum CA724 was positively correlated with the ROMA index (r=0.749,P<0.001). Serum HE4 and the ROMA index were positively correlated(r=0.814,P<0.001). Conclusion The Serum HE4,CA724,and ROMA values can be used as auxiliary examinations to diagnose patients with CA125-negative ovarian cancer. These three indicators can also determine the staging of ovarian cance. This provides an effective reference value for patient diagnosis and treatment.
万方数据
维普
