Relationship between preoperative fibrinogen,hemoglobin,and prothrombin time and postoperative blood transfusion in hip replacement surgery
Objective To analyze the relationship between preoperative fibrinogen,hemoglobin, and prothrombin time and postoperative blood transfusion in hip replacement surgery. Methods A total of 284 patients who underwent hip replacement durgery at West China Hospital of Sichuan University from January 2015 to December 2018 were selected as the research subjects. Ther preoperative general clinical data ,preoperative blood routine,coagulation function and other laboratory test results were collected for all patients. Based on whether they received blod transfusion after surgery ,the patients were divided into two groups:the blood transfusion group(72 cases)and the non-blood transfusion group(212 cases). The general clinical data and relevant laboratory indicators of two groups were compared ,and statistically significant indicators were included in a multi-factor binary regression logistic regression equation to analyze the risk factors affecting blood transfusion after hip replacement. The receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of preoperative fibrinogen,hemoglobin and prothrombin time individual and in combination for postoperative blood transfusion. Results Statistically significant differences were found in age,BMI,hypertension,osteoporosis,surgical duration,fibrinogen,hemoglobin,and prothrombin time between the transfusion group and non transfusion group(P<0.05). Through logistic regression equation analysis,it was determined that an increase in preoperative surgical duration,a decrease in fibrinogen concentration,a desrease in hemoglobin concentration and a prolonged prothrombin time were risk factors for blood transfusion after hip replacement(P<0.05). The combined predictive sensitivity and specificity of fibrinogen,hemoglobin and prothrombin time were 90.27％ and 84.34％,respectively. The AUC was 0.755(P<0.05). Conclusion An increase in preoperative surgical duration,a decrease in fibrinogen concentration,a decrease in hemoglobin concentration and a prolonged prothrombin time are all independent risk factors for postoperative blood transfusion after total hip replacement surgery. These factors have significant predictive value for early detection of the need for postoperative blood transfusion.
FibrinogenHemoglobinProthrombin timeHip replacement surgery
万方数据
维普
