The expression and clinical significance of serum ANGPTL2 and VASH1 in patients with multiple uterine fibroids
Objective To analyze the expression levels of angiopoietin-like protein 2 (ANGPTL2)and vasohibin-1(VASH1)in serum,and to explore their clinical significance in patients with multiple uterine fibroids. Methods A total of 312 patients with multiple uterine fibroids who were treated at the Nanjing Tongren Hospital affiliated with the School of Medicine of Southeast University from January 2018 to January 2022 were included as study subjects(observation group),312 healthy women who visited our hospital for physical examinations were enrolled as controls (control group). Enzyme linked immunosorbent assay (ELISA)was used to measure the levels of ANGPTL2 and VASH1 in serum. Pearson correlation analysis was conducted to examine the relationship between the levels of ANGPTL2 and VASH1 in serum. Receiver operating characteristic(ROC)curve analysis was performed to assess the diagnostic value of serum ANGPTL2 and VASH1 levels for multiple uterine fibroids. Logistic regression was employed to identify the influencing factors of multiple uterine fibroids. Results The levels of ANGPTL2 and VASH1 in the serum of the observation group were significantly higher than those in the control group(t=12.870,9.935,P<0.05). Additionally,the levels of ANGPTL2 and VASH1 in the serum were found to be associated with irregular vaginal bleeding, number of fibroids,maximum fibroid diameter,and average fibroid volume,with statistically significant dif-ference(P<0.05). However,there was no significant association between the levels of ANGPTL2 and SASH1 and age,menstrual status,menopause status,pregnancy history,abortion history,ER,PR and tumor location(P>0.05). Pearson correlation analysis revealed a positive correlation between the levels of ANGPTL2 and VASH1 in the serum of patients with multiple uterine fibroids(r=5.440,P<0.05). The ROC curve analysis results showed that the area under the curve(AUC)of the combination of ANGPTL2 and VASH1 in the diagnosis of multiple uterine fibroids,which was better than that of ANGPTL2 or VASH1 alone(P<0.05). Logistic regression analysis demonstrated that ANGPTL2 and VASH1 were significant influencing factors in the occurrence of multiple uterine fibroids(P<0.05). Conclusion The levels of ANGPTL2 and VASH1 in the serum of patients with multiple uterine fibroids are significantly elevated. The combined measurement of there two markers can assist in the diagnosis of multiple uterine fibroids.
Multiple uterine fibroidsAngiopoietin-like protein 2Vasohibin-1
万方数据
维普
