Effects of ultra-pulse carbon dioxide fractional laser treatment on TGF-β,EGF and bFGF levels changes in female depressed acne scars
Objective to explore the effects of ultra-pulse carbon dioxide fractional laser treatment on transforming growth facto - β(TGF - β), epidermal growth factor (EGF) and basic fibro-blast growth factor(bFGF)levels changes in female depressed acne scars. Methods A total of 104 female patients with depressed acne scars who received treatment at Zigong First People ' s Hospital from April 2020 to February 2022 were selected for this study. According to the treatment plan ,they were divided into two groups:a control group(n=51)receiving conventional surgical treatment and an observation group(n=53)receiving ultrapulse carbon dioxide fractional laser treatment. The study aimed to compare the clinical efficacy , skin conditions,and levels of vascular endothelial factor levels(TGF-β,EGF,and bFGF),recurrence rates, and adverse reaction rates between the two groups. Results The total clinical effective rate in the observation group(84.91％)was higher than that in the control group(62.75％),and the difference was statistically significant (P<0.05). After treatment,the scores for violet,texture,pigmentation and pore in both groups decreased. The scores in the observation group were lower than those in the control group ,and the difference was statistically significant(P<0.05). After treatment,TGF-β and bFGF levels in the observation group were higher than those in the control group,EGF levels were lower than those in the control group,and the difference was statistically significant(P<0.05). The recurrence rate in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05). The total incidence of adverse reactions in the observation group(19.61％)was lower than that in the control group(5.66％),and the difference was statistically significant(P<0.05). Conclusion The application of super-pulsed carbon dioxide dot matrix laser in the treatment of patients with depressed acne scars is effective. It can effectively improve the expression levels of TGF-β,EGF,and bFGF in scar tissue,and it also has better safety.
Super pulsed carbon dioxide fractional laserDepressed acne scarsTGF-βEGFbFGF
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