Relationship between blood routine examination,CRP and the severity and prognosis of neonatal respiratory distress syndrome
Objective To analyze the relationship between blood routine examination ,C-reactive protein (CRP) and the severity and prognosis of neonatal respiratory distress syndrome (NRDS). Methods A total of 100 children with NRDS were admitted to Huainan Maternal and Child Health Hospital from January 2019 to December 2022 and were selected as study subjects. Based on their oxygenation index ,the children were divided into three groups:mild(n=48),moderate(n=33)and severe(n=19). After a 28-day followup,the children who were cured were classified into the good prognosis group(n=69),while those who experienced recurrence,aggravation or death of the disease were classified into the poor prognosis group(n=31).The blood routine examination including red blood cell count(RBC),white blood cell count(WBC),neutrophil count(NEU),lymphocyte count(LYM),platelet count(PLT),neutrophil to lymphocyte ratio(NLR) and CRP levels were compared among all groups. Pearson correlation was used to analyze the relationship between the blood routine index,CRP level and oxygenation index. Multivariate logistic regression was used to analyze the influencing factors of poor prognosis in children with NRDS. The ROC curve was drawn to analyze the value of blood routine indexes and CRP level in evaluating the poor prognosis of children with NRDS. Results There was no significant difference in RBC levels among NRDS patients with different severity(F=0.129,P>0.05). The levels of WBC,NEU,LYM,PLT,NLR and CRP in children with different severity of NRDS were statistically significant(F=5.885,32.335,9.157,14.183,68.810,38.247,P<0.05). Pearson correlation analysis showed that WBC,NEU,NLR and CRP levels were negatively correlated with the oxygenation index,while LYM and PLT were positively correlated with the oxygenation index(P<0.05). The levels of WBC,NEU,NLR and CRP in the good prognosis group were lower than those in the poor prognosis group,and the LYM and PLT were higher than those in the poor prognosis group,with statistical significance(t=3.359,7.063,7.545,9.613,4.471,4.596,P<0.05). Multivariate logistic regression analysis showed that an increased WBC level,increased NEU level,decreased LYM level,decreased PLT level,increased NLR level and increased CRP level were all independent risk factors associated with a poor prognosis in children with NRDS(P<0.05). The ROC curve analysis showed that the area under the curve(AUC)for WBC, NEU,LYM,PLT,NLR and CRP levels and combined detection to evaluate the poor prognosis of NRDS children,respectively. Combined detection was found to be superior to single detection (P<0.05). Conclusion The expression levels of WBC,NEU,LYM,PLT,NLR and CRP in the peripheral blood of children with NRDS are elevated. WBC,NEU,LYM,PLT,NLR and CRP may serve as auxiliary predictors for evaluating the severity and prognosis of NRDS.
万方数据
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