Relationship between miRNA-223,miRNA-21 and miRNA-27a and coronary artery lesions in coronary heart disease
Objective To explore the relationship between miRNA-223,miRNA-21 and miRNA-27a and coronary artery disease and coronary artery disease. Methods A total of 86 CHD patients were admitted to our hospital from January 2021 to December 2022 and were selected as the observation group. Additionally, 70 healthy individuals undergoing physical examination in the hospital during the same period were selected as the control group. The serum levels of miRNA-223,miRNA-21 and miRNA-27a were compared between the two groups. Logistic regression was used to analyze the single and multiple factors affecting CHD coronary artery disease. The serum levels of miRNA-223,miRNA-21 and miRNA-27a were compared among different types of CHD coronary artery disease. The levels of serum miRNA-223,miRNA-21,and miRNA-27a were compared across different counts of CHD coronary artery disease. Results The expression levels of miRNA-223, miRNA-21,and miRNA-27a were higher than those in the control group,and the difference was statistically significant(P<0.05). Logistic multivariate analysis showed that hypertension,diabetes and miRNA-223>1.5, miRNA-21>6.0 and miRNA-27a>5.5 were independent risk factors for coronary disease in CHD(P<0.05). The expression levels of miRNA-223,miRNA-21,and miRNA-27a were as follows:acute myocardial infarction>unstable angina >stable angina,the difference was statistically significant(P<0.05). The expression levels of miRNA-223,miRNA-21,and miRNA-27a were as follows:three>two>single mirNA-27A,the difference was statistically significant(P<0.05). Conclusion The expression levels of miRNA-223,miRNA-21,and miRNA-27a vary in CHD patients with different coronary artery lesions. This suggests that these indicators have clinical value in determining the type of coronary artery lesions in CHD patients.
万方数据
维普
