Effects of terazosin hydrochloride combined with finasteride tablets on clinical efficacy , urinary control function and inflammatory factors in patients with benign prostatic hyperplasia
Objective To analyze the effects of terazosin hydrochloride combined with finasteride tablets on clinical efficacy,urinary control function and inflammatory factors in patients with benign prostatic hyperplasia (BPH). Methods A total of 129 patients with benign prostatic hyperplasia were admitted to Chengdu Jinsha Hospital from July 2019 to January 2023. They were divided into two groups based on their treatment methods:a control group of 63 cases(finasteride tablets)and an observation group of 66 cases(terazosin hydrochloride+finasteride tablets). The overall efficacy rate,prostate volume,IPSS score,urinary control function,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],prostate-specific antigen(PSA),total prostate-specific antigen(tPSA)and adverse reactions were compared between the two groups. Results The total curative effect rate and urinary control rate of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05). After treatment, the prostate volume,IPSS score,IL-6,TNF-α,PSA and tPSA levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05). There was no significant difference in adverse reactions between the two groups(P>0.05). Conclusion Terazosin hydrochloride combined with finasteride tablets in the treatment of BPH patients has shown a high overall efficacy rate. This treatment can significantly improve urinary control function,regulate inflammatory factors,and reduce leveld of PSA and tPSA. The drug is considered safe and reliable.
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